The human intestinal microbiome has coevolved with its host to establish a stable
homeostatic relationship with hallmark features of mutualistic symbioses, yet the mechanistic …

Increasing experimental evidence suggests that administering live commensal bacterial
species can optimize microbiome composition and lead to reduced disease severity and …

The human gut microbiome plays an important role in resisting colonization of the host by
pathogens, but we lack the ability to predict which communities will be protective. We …

Microbial consortia exhibit complex functional properties in contexts ranging from soils to
bioreactors to human hosts. Understanding how community composition determines …

Respiratory microbial dysbiosis is associated with acute respiratory distress syndrome
(ARDS) and hospital-acquired pneumonia (HAP) in critically ill patients. However, we lack …

Progression of chronic liver disease is precipitated by hepatocyte loss, inflammation and
fibrosis. This process results in the loss of critical hepatic functions, increasing morbidity and …

Both genetic susceptibility and environmental factors are important contributors to
autoimmune disease pathogenesis. As an environmental factor, the gut microbiome plays a …

Communities of microorganisms (microbiota) are present in all habitats on Earth and are
relevant for agriculture, health, and climate. Deciphering the mechanisms that determine …

The early-life gut microbiome development has long-term health impacts and can be
influenced by factors such as infant diet. Human milk oligosaccharides (HMOs), an essential …

Non‐gene‐editing microbiome engineering (NgeME) is the rational design and control of
natural microbial consortia to perform desired functions. Traditional NgeME approaches use …