[HTML][HTML] Control of metastasis by NK cells
The metastatic spread of malignant cells to distant anatomical locations is a prominent
cause of cancer-related death. Metastasis is governed by cancer-cell-intrinsic mechanisms …
cause of cancer-related death. Metastasis is governed by cancer-cell-intrinsic mechanisms …
[HTML][HTML] Roles of the RANKL–RANK Axis in Immunity—Implications for Pathogenesis and Treatment of Bone Metastasis
B Li, P Wang, J Jiao, H Wei, W Xu, P Zhou - Frontiers in Immunology, 2022 - frontiersin.org
A substantial amount patients with cancer will develop bone metastases, with 70% of
metastatic prostate and breast cancer patients harboring bone metastasis. Despite …
metastatic prostate and breast cancer patients harboring bone metastasis. Despite …
[HTML][HTML] Molecular profiling and functional analysis of macrophage-derived tumor extracellular vesicles
C Cianciaruso, T Beltraminelli, F Duval, S Nassiri… - Cell reports, 2019 - cell.com
Extracellular vesicles (EVs), including exosomes, modulate multiple aspects of cancer
biology. Tumor-associated macrophages (TAMs) secrete EVs, but their molecular features …
biology. Tumor-associated macrophages (TAMs) secrete EVs, but their molecular features …
[HTML][HTML] Cancer metastasis as a non-healing wound
M Deyell, CS Garris, AM Laughney - British journal of cancer, 2021 - nature.com
Most cancer deaths are caused by metastasis: recurrence of disease by disseminated
tumour cells at sites distant from the primary tumour. Large numbers of disseminated tumour …
tumour cells at sites distant from the primary tumour. Large numbers of disseminated tumour …
Myeloidderived suppressor cells: important contributors to tumor progression and metastasis
E Safarzadeh, M Orangi, H Mohammadi… - Journal of cellular …, 2018 - Wiley Online Library
Myeloidderived suppressor cells (MDSCs) are traditionally considered among the major
components of the immunosuppressive tumor microenvironment (TME). However, there is …
components of the immunosuppressive tumor microenvironment (TME). However, there is …
Potential contributions of antioxidants to cancer therapy: immunomodulation and radiosensitization
A Thyagarajan, RP Sahu - Integrative cancer therapies, 2018 - journals.sagepub.com
Antioxidants play important roles in the maintenance of cellular integrity and thus are critical
in maintaining the homeostasis of the host immune system. A balance between the levels of …
in maintaining the homeostasis of the host immune system. A balance between the levels of …
pHSensitive MolecularSwitchContaining Polymer Nanoparticle for Breast Cancer Therapy with FerritinophagyCascade Ferroptosis and Tumor Immune Activation
T Zuo, T Fang, J Zhang, J Yang, R Xu… - Advanced …, 2021 - Wiley Online Library
Ferritin internalized into tumor cells is degraded and releases iron ions via ferritinophagy.
Iron ions participate in Fenton reaction to produce reactive oxygen species for lipid …
Iron ions participate in Fenton reaction to produce reactive oxygen species for lipid …
Reactive oxygen species (ROS): Critical roles in breast tumor microenvironment
Increases in Reactive oxygen species (ROS) have been reported in breast tumors and their
surrounding tumor microenvironment (TME) cells. ROS are critical factors in breast TME as …
surrounding tumor microenvironment (TME) cells. ROS are critical factors in breast TME as …
[HTML][HTML] IFITM protein regulation and functions: Far beyond the fight against viruses
N Friedlová, F Zavadil Kokáš, TR Hupp… - Frontiers in …, 2022 - frontiersin.org
Interferons (IFNs) are important cytokines that regulate immune responses through the
activation of hundreds of genes, including interferon-induced transmembrane proteins …
activation of hundreds of genes, including interferon-induced transmembrane proteins …
Targeting the tetraspanin CD81 reduces cancer invasion and metastasis
F Vences-Catalán, R Rajapaksa… - Proceedings of the …, 2021 - National Acad Sciences
Tetraspanins are an evolutionary conserved family of proteins involved in multiple aspects of
cell physiology, including proliferation, migration and invasion, protein trafficking, and signal …
cell physiology, including proliferation, migration and invasion, protein trafficking, and signal …