Abstract Changes in nucleolar morphology and function are tightly associated with cellular
activity, such as growth, proliferation, and cell cycle progression. Historically, these …

Transmission and secretion of signals via the choroid plexus (ChP) brain barrier can
modulate brain states via regulation of cerebrospinal fluid (CSF) composition. Here, we …

Forebrain precursor cells are dynamic during early brain development, yet the underlying
molecular changes remain elusive. We observed major differences in transcriptional …

Pluripotent stem cells have been shown to have unique nuclear properties, for example,
hyperdynamic chromatin and large, condensed nucleoli. However, the contribution of the …

Target of rapamycin complex 1 (TORC1) regulates cell growth in response to nutrients and
growth factors. Although TORC1 signaling has been thoroughly studied at the cellular level …

The ubiquitin-like molecule NEDD8 is essential for viability, growth and development, and is
a potential target for therapeutic intervention. We found that the small molecule inhibitor of …

Neural progenitor cells (NPCs) undergo rapid proliferation during neurulation. This rapid
growth generates a high demand for mRNA translation in a timing-dependent manner, but …

Cell growth is well defined for late (postembryonic) stages of development, but evidence for
early (embryonic) cell growth during postmitotic morphogenesis is limited. Here, we report …

In the last larval instar, uncommitted progenitor cells in the Drosophila eye primordium start
to adopt individual retinal cell fates, arrest their growth and proliferation, and initiate terminal …

Choroid plexus tumors and ciliary body medulloepithelioma are predominantly pediatric
neoplasms. Progress in understanding the pathogenesis of these tumors has been hindered …