Rresistance-nodulation-division (RND) efflux pumps in Gram-negative bacteria remove
multiple, structurally distinct classes of antimicrobials from inside bacterial cells therefore …

Bacterial multidrug efflux systems are a major mechanism of antimicrobial resistance and
are fundamental to the physiology of Gram-negative bacteria. The resistance-nodulation …

Klebsiella pneumoniae is a significant human pathogen, in part due to high rates of
multidrug resistance. RamA is an intrinsic regulator in K. pneumoniae established to be …

In Enterobacteriaceae, membrane permeability is a≪ key≫ in the level of susceptibility to
antibiotics. Modification of the bacterial envelope by decreasing the porin production or …

Our ability to connect genotypic variation to biologically important phenotypes has been
seriously limited by the gap between live-cell microscopy and library-scale genomic …

Bacteria have a great capacity for adjusting their metabolism in response to environmental
changes by linking extracellular stimuli to the regulation of genes by transcription factors. By …

The transport of small molecules across membranes is essential for the import of nutrients
and other energy sources into the cell and, for the export of waste and other potentially …

Environments inhabited by Enterobacteriaceae are diverse and often stressful. This is
particularly true for Escherichia coli and Salmonella during host association in the …

Mechanisms of antibiotic resistance were examined in nalidixic acid-resistant Salmonella
enterica serovar Enteritidis field isolates displaying decreased susceptibility to ciprofloxacin …

The transport of small molecules across membranes is a pivotal step for controlling the drug
concentration into the bacterial cell and it efficiently contributes to the antibiotic susceptibility …