The human immunoglobulin repertoire is a hugely diverse set of sequences that are formed
by processes of gene rearrangement, heavy and light chain gene assortment, class …

Accumulating evidence supports the concept of increased thrombin generation, placental
vascular lesions, and inflammation as crucial points in the development of the great …

Objective Pathogenic antiphospholipid antibodies (aPL) bind the self antigen N‐terminal
domain (domain I) of β2‐glycoprotein I (β2GPI), with residues G40–R43 being important …

Antibody diversity occurs randomly as B cells recombine their immunoglobulin (Ig) heavy-
and light-chain genes during development. This process inevitably generates reactivity …

Objective Inflammatory disease activity in patients with systemic lupus erythematosus (SLE)
may affect the development of atherosclerosis, contributing to their increased risk of …

A major mechanism of hypercoagulability in the antiphospholipid syndrome (APS) is
antiphospholipid Ab-mediated upregulation of tissue factor (TF) on monocytes via activation …

Problem Some patients with antiphospholipid syndrome (APS) suffer pregnancy morbidity
(PM) but not vascular thrombosis (VT), whilst others suffer VT only. Therefore, we compared …

Antiphospholipid antibodies (aPL) cause vascular thrombosis (VT) and/or pregnancy
morbidity (PM). Differential mechanisms however, underlying the pathogenesis of these …

Traditional antibody-mediated neutralization of HIV-1 infection is thought to result from the
binding of antibodies to virions, thus preventing virus entry. However, antibodies that broadly …

It is generally accepted that the major autoantigen for antiphospholipid antibodies (aPL) in
the antiphospholipid syndrome (APS) is β 2-glycoprotein I (β 2 GPI). However, a recent study …