AUTS2 Gene: Keys to Understanding the Pathogenesis of Neurodevelopmental Disorders

K Hori, K Shimaoka, M Hoshino - Cells, 2021 - mdpi.com
Neurodevelopmental disorders (NDDs), including autism spectrum disorders (ASD) and
intellectual disability (ID), are a large group of neuropsychiatric illnesses that occur during …

The synaptic and circuit functions of vitamin D in neurodevelopment disorders

X Ye, Q Zhou, P Ren, W Xiang… - … Disease and Treatment, 2023 - Taylor & Francis
Vitamin D deficiency/insufficiency is a public health issue around the world. According to
epidemiological studies, low vitamin D levels have been associated with an increased risk of …

[HTML][HTML] Brain Dp140 alters glutamatergic transmission and social behaviour in the mdx52 mouse model of Duchenne muscular dystrophy

Y Hashimoto, H Kuniishi, K Sakai, Y Fukushima… - Progress in …, 2022 - Elsevier
Duchenne muscular dystrophy (DMD) is a muscle disorder caused by DMD mutations and is
characterized by neurobehavioural comorbidities due to dystrophin deficiency in the brain …

Auts2 deletion involves in DG hypoplasia and social recognition deficit: The developmental and neural circuit mechanisms

J Li, X Sun, Y You, Q Li, C Wei, L Zhao, M Sun… - Science …, 2022 - science.org
The involvement of genetic risk and the underlying developmental and neural circuit
mechanisms in autism-related social deficit are largely unclear. Here, we report that deletion …

Autism-related transcription factors underlying the sex-specific effects of prenatal bisphenol a exposure on transcriptome-interactome profiles in the offspring prefrontal …

S Kanlayaprasit, S Thongkorn, P Panjabud… - International Journal of …, 2021 - mdpi.com
Bisphenol A (BPA) is an environmental risk factor for autism spectrum disorder (ASD). BPA
exposure dysregulates ASD-related genes in the hippocampus and neurological functions …

Cerebral organoids containing an AUTS2 missense variant model microcephaly

SR Fair, W Schwind, DL Julian, A Biel, G Guo… - Brain, 2023 - academic.oup.com
Variants in the AUTS2 gene are associated with a broad spectrum of neurological conditions
characterized by intellectual disability, microcephaly, and congenital brain malformations …

Investigation of autism-related transcription factors underlying sex differences in the effects of bisphenol A on transcriptome profiles and synaptogenesis in the …

S Thongkorn, S Kanlayaprasit, K Kasitipradit… - Biology of sex …, 2023 - Springer
Abstract Background Bisphenol A (BPA) has been linked to susceptibility to autism spectrum
disorder (ASD). Our recent studies have shown that prenatal BPA exposure disrupted ASD …

AUTS2 governs cerebellar development, purkinje cell maturation, motor function and social communication

K Yamashiro, K Hori, ESK Lai, R Aoki, K Shimaoka… - IScience, 2020 - cell.com
Summary Autism susceptibility candidate 2 (AUTS2), a risk gene for autism spectrum
disorders (ASDs), is implicated in telencephalon development. Because AUTS2 is also …

Transcriptomic signatures associated with underlying rapid changes in the early phase brain of bi-directional sex change in Trimma okinawae

K Tamagawa, T Sunobe… - Royal Society Open …, 2023 - royalsocietypublishing.org
Teleost fish exhibit remarkable sexual plasticity and divergent developmental systems,
including sequential hermaphroditism. One of the more fascinating models of sexual …

Voluntary exercise ameliorates synaptic pruning deficits in sleep-deprived adolescent mice

LH Tuan, CY Tsao, LJH Lee, LJ Lee - Brain, Behavior, and Immunity, 2021 - Elsevier
Adolescence is a critical period for brain development and adequate sleep during this
period is essential for physical function and mental health. Emerging evidence has detailed …