Members of the MAGUK family proteins cluster receptors and intracellular signaling
molecules at the neuronal synapse. We report that genetic inactivation of the MAGUK family …

T cell receptor (TCR) signaling plays an important role in early interleukin (IL)-4 production
by naive CD4+ T cells. This “antigen-stimulated” early IL-4 is sufficient for in vitro Th2 …

NF-κB signaling is required for the maintenance of normal B lymphocytes, whereas
dysregulated NF-κB activation contributes to B cell lymphomas. The events that regulate NF …

Protein kinase C (PKC) θ is an established component of the immunological synapse and
has been implicated in the control of AP-1 and NF-κB. To study the physiological function of …

In recent years, substantial progress has been made towards the identification of
intracellular signalling molecules that couple multi-subunit immune-recognition receptors …

Protein kinase C molecules regulate both positive and negative signal transduction
pathways essential for the initiation and homeostasis of immune responses. There are …

CARMA1 is a lymphocyte-specific member of the membrane-associated guanylate kinase
(MAGUK) family of scaffolding proteins, which coordinate signaling pathways emanating …

Abstract The Carma1-Bcl10-Malt1 signaling module bridges TCR signaling to the canonical
IκB kinase (IKK)/NF-κB pathway. Covalent attachment of regulatory ubiquitin chains to Malt1 …

The specificity of the adaptive immune response is, in part, dependent on the clonal
expression of the mature T cell receptor (TCR) on T lymphocytes. One mechanism …

Costimulation is a concept that goes back to the early 1980s when Lafferty and others
hypothesized that cell surface and soluble molecules must exist that are essential for …