Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …

In recent decades, immune checkpoint blockade and chimeric antigen receptor T cell (CAR-
T) therapy are two milestone achievements in clinical immunotherapy. However, both show …

Artificial sweeteners are used as calorie-free sugar substitutes in many food products and
their consumption has increased substantially over the past years. Although generally …

Abstract Coronavirus disease 2019 (COVID-19) is a respiratory infectious disease caused
by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is …

Over the last decade remarkable progress has been made in enhancing the efficacy of CAR
T therapies. However, the clinical benefits are still limited, especially in solid tumors. Even in …

Regulatory T cells (Tregs) are present in lymphoid and nonlymphoid tissues where they
restrict immune activation, prevent autoimmunity, and regulate inflammation. Tregs in …

Zinc is an essential micronutrient with crucial roles in multiple facets of biological processes.
Dysregulated zinc homeostasis impairs overall immune function and resultantly increases …

How lipidome changes support CD8+ effector T (Teff) cell differentiation is not well
understood. Here we show that, although naive T cells are rich in polyunsaturated …

Atherosclerosis is a chronic inflammatory disease driven by hypercholesterolemia. During
aging, T cells accumulate cholesterol, potentially affecting inflammation. However, the effect …

NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was
identified as a pivotal pathway in mediating inflammatory responses. However, with …