Our physiology and behavior follow precise daily programs that adapt us to the alternating
opportunities and challenges of day and night. Under experimental isolation, these rhythms …

The 24 h (circadian) timing system develops in mammals during the perinatal period. It
carries out the essential task of anticipating daily recurring environmental changes to identify …

Circadian clocks confer 24-h periodicity to biological systems, to ultimately maximize energy
efficiency and promote survival in a world with regular environmental light cycles. In …

Sleep plays an essential role in all studied animals with a nervous system. However, sleep
deprivation leads to various pathological changes and neurobehavioral problems …

Tauopathies, a group of neurodegenerative diseases that includes Alzheimer's disease,
commonly lead to disturbances in sleep-wake patterns and circadian rhythm disorders. The …

The study of functions, mechanisms of generation, and pathways of movement of cerebral
fluids has a long history, but the last decade has been especially productive. The proposed …

The neurovascular system forms the interface between the tissue of the central nervous
system (CNS) and circulating blood. It plays a critical role in regulating movement of ions …

Simple Summary NPAS2, short for Neuronal PAS Domain Protein 2, is a transcription factor
involved in regulating the circadian rhythms and sleep–wake cycles in mammals, including …

Living organisms navigate through a cyclic world: activity, feeding, social interactions are all
organized along the periodic succession of night and day. At the cellular level, periodic …

Sleep and circadian rhythms are observed broadly throughout animal phyla and influence
neural plasticity and cognitive function. However, the few phylogenetically conserved …