Epistasis occurs when the effect of a mutation depends on its carrier's genetic background.
Despite increasing evidence that epistasis for fitness is common, its role during evolution is …

Evolution has traditionally been a historical and descriptive science, and predicting future
evolutionary processes has long been considered impossible. However, evolutionary …

The molecular chaperone Hsp90 (Heat shock protein, 90 kDa) is an abundant and essential
cytosolic protein required for the stability and/or folding of hundreds of client proteins …

Understanding the allosteric mechanisms of the Hsp90 chaperone interactions with
cochaperones and client protein clientele is fundamental to dissect activation and regulation …

Protein allostery requires a communication channel for functional regulation between distal
sites within a protein. In the molecular chaperone Hsp70, a two-domain enzyme, the …

Hsp90 is an abundant and essential molecular chaperone that mediates the folding and
activation of client proteins in a nucleotide-dependent cycle. Hsp90 inhibition directly or …

Cellular lineage tracking provides a means to observe population makeup at the clonal
level, allowing exploration of heterogeneity, evolutionary and developmental processes and …

Anti-clustered regularly interspaced short palindromic repeats (CRISPRs) are proteins
capable of blocking CRISPR-Cas systems and typically their genes are located on mobile …

Hsp90 is a crucial molecular chaperone that regulates proteostasis by facilitating the
refolding and activation of various signaling proteins. Its importance in protein folding and …

Anti-CRISPRs are molecules typically encoded in mobile elements and capable of blocking
CRISPR-Cas systems. Since their discovery, numerous anti-CRISPR families have been …