The history of hepatitis C virus (HCV): Basic research reveals unique features in phylogeny, evolution and the viral life cycle with new perspectives for epidemic control

J Bukh - Journal of hepatology, 2016 - Elsevier
The discovery of hepatitis C virus (HCV) in 1989 permitted basic research to unravel critical
components of a complex life cycle for this important human pathogen. HCV is a highly …

Replication of hepatitis C virus

D Moradpour, F Penin, CM Rice - Nature reviews microbiology, 2007 - nature.com
Exciting progress has recently been made in understanding the replication of hepatitis C
virus, a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma …

Immunobiology and pathogenesis of viral hepatitis

LG Guidotti, FV Chisari - Annu. Rev. Pathol. Mech. Dis., 2006 - annualreviews.org
Among the many viruses that are known to infect the human liver, hepatitis B virus (HBV)
and hepatitis C virus (HCV) are unique because of their prodigious capacity to cause …

Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity

XD Li, L Sun, RB Seth, G Pineda… - Proceedings of the …, 2005 - National Acad Sciences
Hepatitis C virus (HCV) is a global epidemic manifested mainly by chronic infection. One
strategy that HCV employs to establish chronic infection is to use the viral Ser protease …

Replication of hepatitis C virus

R Bartenschlager, V Lohmann - Journal of general …, 2000 - microbiologyresearch.org
After the development of diagnostic tests for hepatitis A and hepatitis B viruses in the 1970s,
an additional parenterally transmitted agent responsible for the majority of …

Identification and properties of the RNA‐dependent RNA polymerase of hepatitis C virus.

SE Behrens, L Tomei, R De Francesco - The EMBO journal, 1996 - embopress.org
Hepatitis C virus (HCV) is the major etiological agent of non‐A, non‐B post‐transfusion
hepatitis. Its genome, a (+)‐stranded RNA molecule of approximately 9.4 kb, encodes a …

Expression and identification of hepatitis C virus polyprotein cleavage products

A Grakoui, C Wychowski, C Lin, SM Feinstone… - Journal of …, 1993 - Am Soc Microbiol
Hepatitis C virus (HCV) is the major cause of transfusion-acquired non-A, non-B hepatitis.
HCV is an enveloped positive-sense RNA virus which has been classified as a new genus …

Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase

MJ Sofia, W Chang, PA Furman… - Journal of medicinal …, 2012 - ACS Publications
Hepatitis C virus (HCV) infection is a global health problem that impacts approximately 180
million individuals. Of those initially infected with HCV approximately 80% will progress to …

Stealth and cunning: hepatitis B and hepatitis C viruses

SF Wieland, FV Chisari - Journal of virology, 2005 - Am Soc Microbiol
The hepatitis B virus (HBV) and hepatitis C virus (HCV) are noncytopathic, hepatotropic
members of the hepadnavirus (HBV) and ffavivirus (HCV) families that cause acute and …

[HTML][HTML] Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide

JL Kim, KA Morgenstern, C Lin, T Fox, MD Dwyer… - Cell, 1996 - cell.com
An estimated 1% of the global human population is infected by hepatitis C viruses (HCVs),
and there are no broadly effective treatments for the debilitating progression of chronic …