Catharanthus roseus is a medicinal plant belonging to the family Apocynaceae which
produces terpenoid indole alkaloids (TIAs) of high medicinal importance. Indeed, a number …

Stroke remains a leading cause of adult disability. Some degree of spontaneous behavioral
recovery is usually seen in the weeks after stroke onset. Variability in recovery is substantial …

Recently, the inflammatory and neurodegenerative (I&ND) hypothesis of depression was
formulated (Maes et al., 2009), ie the neurodegeneration and reduced neurogenesis that …

Astrocytes are the main neural cell type responsible for the maintenance of brain
homeostasis. They form highly organized anatomical domains that are interconnected into …

Sickness refers to a coordinated set of subjective, behavioural and physiological changes
that develop in sick individuals during the course of an infection. These changes are due to …

The idea of the existence of an interaction between the immune system and the central
nervous system (CNS) has prompted extensive research interest into the subject of “ …

J. Neurochem.(2012) 120, 1060–1071. Abstract This study describes the effects of long‐
chain fatty acids on inflammatory signaling in cultured astrocytes. Data show that the …

Clinical experimental stroke induces injurious local brain inflammation. However, effects on
the peripheral immune system have not been well characterized. We quantified mRNA and …

Adenosine is a neuromodulator that operates via the most abundant inhibitory adenosine A
1 receptors (A 1 Rs) and the less abundant, but widespread, facilitatory A 2A Rs. It is …

Accumulating evidence suggests that there is a rich cross-talk between the neuroimmune
system and neuroplasticity mechanisms under both physiological conditions and …