Detecting polygenic evolution: problems, pitfalls, and promises

M Wellenreuther, B Hansson - TRENDS in Genetics, 2016 - cell.com
Unraveling the genetic basis of organismal form and function remains one of the major goals
of evolutionary biology. Theory has long supported a model of polygenic evolution in which …

The QTN program and the alleles that matter for evolution: all that's gold does not glitter

MV Rockman - Evolution, 2012 - academic.oup.com
The search for the alleles that matter, the quantitative trait nucleotides (QTNs) that underlie
heritable variation within populations and divergence among them, is a popular pursuit. But …

Human adaptation over the past 40,000 years

I Mathieson - Current opinion in genetics & development, 2020 - Elsevier
Over the past few years several methodological and data-driven advances have greatly
improved our ability to robustly detect genomic signatures of selection in humans. New …

Integrated environmental and genomic analysis reveals the drivers of local adaptation in African indigenous chickens

AA Gheyas, A Vallejo-Trujillo, A Kebede… - Molecular biology …, 2021 - academic.oup.com
Breeding for climate resilience is currently an important goal for sustainable livestock
production. Local adaptations exhibited by indigenous livestock allow investigating the …

Catch me if you can: adaptation from standing genetic variation to a moving phenotypic optimum

S Matuszewski, J Hermisson, M Kopp - Genetics, 2015 - academic.oup.com
Adaptation lies at the heart of Darwinian evolution. Accordingly, numerous studies have tried
to provide a formal framework for the description of the adaptive process. Of these, two …

Broad-scale variation in human genetic diversity levels is predicted by purifying selection on coding and non-coding elements

DA Murphy, E Elyashiv, G Amster, G Sella - Elife, 2022 - elifesciences.org
Analyses of genetic variation in many taxa have established that neutral genetic diversity is
shaped by natural selection at linked sites. Whether the mode of selection is primarily the …

Fisher's geometric model with a moving optimum

S Matuszewski, J Hermisson, M Kopp - Evolution, 2014 - academic.oup.com
Fisher's geometric model has been widely used to study the effects of pleiotropy and
organismic complexity on phenotypic adaptation. Here, we study a version of Fisher's model …

A Variable Genetic Architecture of Melanic Evolution in Drosophila melanogaster

H Bastide, JD Lange, JB Lack, A Yassin, JE Pool - Genetics, 2016 - academic.oup.com
Unraveling the genetic architecture of adaptive phenotypic divergence is a fundamental
quest in evolutionary biology. In Drosophila melanogaster, high-altitude melanism has …

A theory of oligogenic adaptation of a quantitative trait

I Höllinger, B Wölfl, J Hermisson - Genetics, 2023 - academic.oup.com
Rapid phenotypic adaptation is widespread in nature, but the underlying genetic dynamics
remain controversial. Whereas population genetics envisages sequential beneficial …

[PDF][PDF] Chasing the mechanisms of ecologically adaptive salinity tolerance

S Busoms, S Fischer, L Yant - Plant Communications, 2023 - cell.com
Plants adapted to challenging environments offer fascinating models of evolutionary
change. Importantly, they also give information to meet our pressing need to develop …