Ultrasound‐activated oxygen and ROS generation nanosystem systematically modulates tumor microenvironment and sensitizes sonodynamic therapy for hypoxic …

J Fu, T Li, Y Zhu, Y Hao - Advanced Functional Materials, 2019 - Wiley Online Library
Sonodynamic therapy (SDT) is noninvasive and possesses high body‐penetration depth,
showing great potential for the treatment of deep‐seated solid tumors. The efficacy of SDT …

Cancer cell membrane camouflaged iridium complexes functionalized black-titanium nanoparticles for hierarchical-targeted synergistic NIR-II photothermal and …

J Shen, J Karges, K Xiong, Y Chen, L Ji, H Chao - Biomaterials, 2021 - Elsevier
The diagnosis and treatment of cancer is one of the biggest medical challenges of the
century. Despite significant improvements, there remains an urgent need for novel …

Fluorination‐induced multi‐enhancement of a Nano‐photosensitizer for deep photodynamic therapy against hypoxia tumor

K Wei, Y Wu, X Zheng, G Ma, C Ji… - Advanced Functional …, 2023 - Wiley Online Library
Organic dyes hold great promise for application in photodynamic therapy (PDT). However,
they currently face challenges such as inadequate photodynamic activity, limited tumor …

Multifunctional mesoporous silica nanoparticles for biomedical applications

B Xu, S Li, R Shi, H Liu - Signal Transduction and Targeted Therapy, 2023 - nature.com
Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of
nanotechnology applied in the biomedical field, due to their easily tunable structure and …

Advanced nanotechnology leading the way to multimodal imaging‐guided precision surgical therapy

C Wang, W Fan, Z Zhang, Y Wen, L Xiong… - Advanced …, 2019 - Wiley Online Library
Surgical resection is the primary and most effective treatment for most patients with solid
tumors. However, patients suffer from postoperative recurrence and metastasis. In the past …

Redox regulation and its emerging roles in cancer treatment

H Zhang, Z Mao, Y Kang, W Zhang, L Mei… - Coordination Chemistry …, 2023 - Elsevier
Intracellular reduction–oxidation (redox) homeostasis, mediated mainly by reactive oxygen
species (ROS), plays a significant role in physiological function maintenance and regulation …

Ultrasound-responsive matters for biomedical applications

D Huang, J Wang, C Song, Y Zhao - The Innovation, 2023 - cell.com
Ultrasound (US) is a biofavorable mechanical wave that has shown practical significance in
biomedical fields. Due to the cavitation effect, sonoluminescence, sonoporation, pyrolysis …

Graphene Quantum Dots with Pyrrole N and Pyridine N: Superior Reactive Oxygen Species Generation Efficiency for Metal‐Free Sonodynamic Tumor Therapy

S Yang, X Wang, P He, A Xu, G Wang, J Duan, Y Shi… - Small, 2021 - Wiley Online Library
Those responsible for the development of sonosensitizers are faced with a dilemma
between high sonosensitization efficacy and good biosecurity that limited the development …

Research progress on tumor hypoxia-associative nanomedicine

XX Xu, SY Chen, NB Yi, X Li, SL Chen, Z Lei… - Journal of Controlled …, 2022 - Elsevier
Hypoxia at the solid tumor site is generally related to the unrestricted proliferation and
metabolism of cancerous cells, which can cause tumor metastasis and aggravate tumor …

Activating drugs with sound: mechanisms behind sonodynamic therapy and the role of nanomedicine

V Choi, MA Rajora, G Zheng - Bioconjugate Chemistry, 2020 - ACS Publications
Sonodynamic therapy (SDT) is a promising therapeutic platform for minimally invasive
cancer treatment in which acoustically susceptible drug agents, sonosensitizers, are …