Amyotrophic lateral sclerosis (ALS) is a devastating disease caused by degeneration of
motor neurons. As with all major neurodegenerative disorders, development of disease …

Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional
remodeling in response to injury, disease, or infection of the CNS. Although this remodeling …

Microglia are the resident macrophages of the central nervous system (CNS) acting as the
first line of defense in the brain by phagocytosing harmful pathogens and cellular debris …

Neuroinflammation is associated with neurodegenerative diseases, such as Alzheimer's
disease, Parkinson's disease, and amyotrophic lateral sclerosis. Microglia and astrocytes …

Advanced glycation end products (AGEs) are formed in non-enzymatic reaction, oxidation,
rearrangement and cross-linking between the active carbonyl groups of reducing sugars …

Microglia, being the resident immune cells of the central nervous system, play an important
role in maintaining tissue homeostasis and contributes towards brain development under …

The neuroimmune system is involved in development, normal functioning, aging, and injury
of the central nervous system. Microglia, first described a century ago, are the main …

Major depressive disorder represents a serious public health challenge worldwide;
however, the underlying cellular and molecular mechanisms are mostly unknown. Here, we …

Reactive astrocytes have been implicated in the pathogenesis of neurodegenerative
diseases, including a non-cell autonomous effect on motor neuron survival in ALS. We …

Activation of microglia is a prominent pathological feature in tauopathies, including
Alzheimer's disease. How microglia activation contributes to tau toxicity remains largely …