Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders

VS Sohal, JLR Rubenstein - Molecular psychiatry, 2019 - nature.com
Abstract In 2003 Rubenstein and Merzenich hypothesized that some forms of Autism (ASD)
might be caused by a reduction in signal-to-noise in key neural circuits, which could be the …

Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications

Z Yan, B Rein - Molecular psychiatry, 2022 - nature.com
The prefrontal cortex (PFC) serves as the chief executive officer of the brain, controlling the
highest level cognitive and emotional processes. Its local circuits among glutamatergic …

[HTML][HTML] Human gut microbiota from autism spectrum disorder promote behavioral symptoms in mice

G Sharon, NJ Cruz, DW Kang, MJ Gandal, B Wang… - Cell, 2019 - cell.com
Autism spectrum disorder (ASD) manifests as alterations in complex human behaviors
including social communication and stereotypies. In addition to genetic risks, the gut …

A systematic comparison of neurotoxicity of bisphenol A and its derivatives in zebrafish

J Gu, M Guo, X Yin, C Huang, L Qian, L Zhou… - Science of the Total …, 2022 - Elsevier
As more and more countries have prohibited the manufacture and sale of plastic products
with bisphenol A (BPA), a number of bisphenol analogues (BPs), including BPS, BPF and …

[HTML][HTML] Circuitry underlying experience-dependent plasticity in the mouse visual system

BM Hooks, C Chen - Neuron, 2020 - cell.com
Since the discovery of ocular dominance plasticity, neuroscientists have understood that
changes in visual experience during a discrete developmental time, the critical period …

[HTML][HTML] Gabapentin and pregabalin in bipolar disorder, anxiety states, and insomnia: Systematic review, meta-analysis, and rationale

JSW Hong, LZ Atkinson, N Al-Juffali, A Awad… - Molecular …, 2022 - nature.com
The gabapentinoids, gabapentin, and pregabalin, target the α2δ subunits of voltage-gated
calcium channels. Initially licensed for pain and seizures, they have become widely …

Neurotoxicity of polystyrene nanoplastics with different particle sizes at environment-related concentrations on early zebrafish embryos

R Zhou, D Zhou, S Yang, Z Shi, H Pan, Q Jin… - Science of The Total …, 2023 - Elsevier
Nanoplastics (NPs) have received global attention due to their wide application and
detection in various environmental or biological media. NPs can penetrate physical barriers …

A review of decreased sound tolerance in autism: Definitions, phenomenology, and potential mechanisms

ZJ Williams, JL He, CJ Cascio… - … & Biobehavioral Reviews, 2021 - Elsevier
Atypical behavioral responses to environmental sounds are common in autistic children and
adults, with 50–70% of this population exhibiting decreased sound tolerance (DST) at some …

[HTML][HTML] Autism spectrum disorder: focus on glutamatergic neurotransmission

M Montanari, G Martella, P Bonsi… - International Journal of …, 2022 - mdpi.com
Disturbances in the glutamatergic system have been increasingly documented in several
neuropsychiatric disorders, including autism spectrum disorder (ASD). Glutamate-centered …

Distinct patterns of neural habituation and generalization in children and adolescents with autism with low and high sensory overresponsivity

SA Green, L Hernandez, KE Lawrence… - American Journal of …, 2019 - Am Psychiatric Assoc
Objective: Sensory overresponsivity (SOR), an atypical negative reaction to sensory stimuli,
is highly prevalent in autism spectrum disorder (ASD). Previous work has related SOR to …