[HTML][HTML] Testing the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: in vivo neurospectroscopy and molecular evidence …
Abstract Background Excitation/inhibition (E/I) imbalance remains a widely discussed
hypothesis in autism spectrum disorders (ASD). The presence of such an imbalance may …
hypothesis in autism spectrum disorders (ASD). The presence of such an imbalance may …
[HTML][HTML] Advances toward precision therapeutics for developmental and epileptic encephalopathies
I Bertocchi, M Cambiaghi, MT Hasan - Frontiers in Neuroscience, 2023 - frontiersin.org
Developmental and epileptic encephalopathies are childhood syndromes of severe epilepsy
associated with cognitive and behavioral disorders. Of note, epileptic seizures represent …
associated with cognitive and behavioral disorders. Of note, epileptic seizures represent …
[HTML][HTML] A microRNA-based gene-targeting tool for virally labeling interneurons in the rodent cortex
More specific and broadly applicable viral gene-targeting tools for labeling neuron subtypes
are needed to advance neuroscience research, especially in rodent transgenic disease …
are needed to advance neuroscience research, especially in rodent transgenic disease …
[HTML][HTML] Transcranial direct current stimulation (tDCS) can modulate EEG complexity of children with autism spectrum disorder
J Kang, E Cai, J Han, Z Tong, X Li… - Frontiers in …, 2018 - frontiersin.org
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder which
affects the developmental trajectory in several behavioral domains, including impairments of …
affects the developmental trajectory in several behavioral domains, including impairments of …
[HTML][HTML] LRRTM4: a novel regulator of presynaptic inhibition and ribbon synapse arrangements of retinal bipolar cells
R Sinha, TJ Siddiqui, N Padmanabhan, J Wallin… - Neuron, 2020 - cell.com
LRRTM4 is a transsynaptic adhesion protein regulating glutamatergic synapse assembly on
dendrites of central neurons. In the mouse retina, we find that LRRTM4 is enriched at …
dendrites of central neurons. In the mouse retina, we find that LRRTM4 is enriched at …
[HTML][HTML] Conditional knockout of Shank3 in the ventral CA1 by quantitative in vivo genome-editing impairs social memory in mice
Individuals with autism spectrum disorder (ASD) have a higher prevalence of social memory
impairment. A series of our previous studies revealed that hippocampal ventral CA1 (vCA1) …
impairment. A series of our previous studies revealed that hippocampal ventral CA1 (vCA1) …
[HTML][HTML] The GABAB receptor agonist STX209 reverses the autism‑like behaviour in an animal model of autism induced by prenatal exposure to valproic acid
S Jiang, L Xiao, Y Sun, M He… - Molecular …, 2022 - spandidos-publications.com
Autism spectrum disorder (ASD) is a lifelong neurodevelopmental condition characterized
by impaired social interaction, compromised communication, and restrictive or stereotyped …
by impaired social interaction, compromised communication, and restrictive or stereotyped …
[HTML][HTML] Chemogenetic rectification of the inhibitory tone onto hippocampal neurons reverts autistic-like traits and normalizes local expression of estrogen receptors in …
Female, but not male, mice with haploinsufficiency for the proautophagic Ambra1 gene show
an autistic-like phenotype associated with hippocampal circuits dysfunctions which include …
an autistic-like phenotype associated with hippocampal circuits dysfunctions which include …
[HTML][HTML] Prenatal GABAB receptor agonist administration corrects the inheritance of autism-like core behaviors in offspring of mice prenatally exposed to valproic acid
S Jiang, M He, L Xiao, Y Sun, J Ding, W Li… - Frontiers in …, 2022 - frontiersin.org
This study was performed to evaluate the effects of prenatal baclofen (a GABAB receptor
agonist) treatment on the inheritance of autism-like behaviors in valproic acid (VPA) …
agonist) treatment on the inheritance of autism-like behaviors in valproic acid (VPA) …
fmr1 mutation alters the early development of sensory coding and hunting and social behaviors in larval zebrafish
Autism spectrum disorders (ASDs) are developmental in origin; however, little is known
about how they affect the early development of behavior and sensory coding. The most …
about how they affect the early development of behavior and sensory coding. The most …