In the healthy brain, gamma-aminobutyric acid (GABA) is regulated by neurons and glia.
This begs the question: what happens in the malfunctioning brain? There are many reasons …

Impairments in synapse development are thought to cause numerous psychiatric disorders.
Autism susceptibility candidate 2 (AUTS2) gene has been associated with various …

Astrocytes are implicated in synapse formation and elimination, which are associated with
developmental refinements of neuronal circuits. Astrocyte dysfunctions are also linked to …

A leading theory holds that neurodevelopmental brain disorders arise from imbalances in
excitatory and inhibitory (E/I) brain circuitry. However, it is unclear whether this one …

Impairments of the dialog between excitation and inhibition (E/I) is commonly associated to
neuropsychiatric disorders like autism, bipolar disorders and epilepsy. Moderate levels of …

Many genes have been linked to autism. However, it remains unclear what long-term
changes in neural circuitry result from disruptions in these genes, and how these circuit …

Defining neuronal cell types and their associated biophysical and synaptic diversity has
become an important goal in neuroscience as a mechanism to create comprehensive brain …

Abstract The human 16p11. 2 gene locus is a hot spot for copy number variations, which
predispose carriers to a range of neuropsychiatric phenotypes. Microduplications of 16p11 …

The synaptic balance between excitation and inhibition (E/I balance) is a fundamental
principle of cortical circuits, and disruptions in E/I balance are commonly linked to cognitive …

To diagnose autism spectrum disorder (ASD), researchers have sought biomarkers whose
alterations correlate with the susceptibility to ASD. However, biomarkers closely related to …