Schizophrenia is a chronic disorder characterized by specific positive and negative primary
symptoms, social behavior disturbances and cognitive deficits (eg, impairment in working …

The mechanistic underpinnings of autism remain a subject of debate and controversy. Why
do individuals with autism share an overlapping set of atypical behaviors and symptoms …

Early prenatal inflammatory conditions are thought to be a risk factor for different
neurodevelopmental disorders. Maternal interleukin-6 (IL-6) elevation during pregnancy …

Distinct genetic forms of autism are hypothesized to share a common increase in excitation-
inhibition (EI) ratio in cerebral cortex, causing hyperexcitability and excess spiking. We …

Neuroinflammation impacts the brain and cognitive behavior through microglial activation. In
this study, we determined the temporal sequence from microglial activation to synaptic …

Computational models in neuroscience typically contain many parameters that are poorly
constrained by experimental data. Uncertainty quantification and sensitivity analysis provide …

Cortical activity has distinct features across scales, from the spiking statistics of individual
cells to global resting-state networks. We here describe the first full-density multi-area …

Background Individuals on the autism spectrum have been long described to process
sensory information differently than neurotypical individuals. While much effort has been …

Emerging research on neuroplasticity processes in psychosis spectrum illnesses—from the
synaptic to the macrocircuit levels—fill key gaps in our models of pathophysiology and open …

Fragile X Syndrome (FXS) is a leading inherited cause of autism and intellectual disability,
resulting from a mutation in the FMR1 gene and subsequent loss of its protein product …