Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy
The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to
import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in …
import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in …
Biomarkers of oxidative stress and antioxidant defense
A number of reactive oxygen and nitrogen species are produced during normal metabolism
in human body. These species can be both radical and non-radical and have varying …
in human body. These species can be both radical and non-radical and have varying …
[HTML][HTML] The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species
Initially adopted as a mucolytic about 60 years ago, the cysteine prodrug N-acetylcysteine
(NAC) is the standard of care to treat paracetamol intoxication, and is included on the World …
(NAC) is the standard of care to treat paracetamol intoxication, and is included on the World …
Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …
Nutritional significance of amino acids, vitamins and minerals as nutraceuticals in poultry production and health–a comprehensive review
Nutraceuticals have gained immense importance in poultry science recently considering the
nutritional and beneficial health effects of their constituents. Besides providing nutritional …
nutritional and beneficial health effects of their constituents. Besides providing nutritional …
[HTML][HTML] Emerging mechanisms and targeted therapy of ferroptosis in cancer
H Wang, Y Cheng, C Mao, S Liu, D Xiao, J Huang… - Molecular Therapy, 2021 - cell.com
Ferroptosis is an iron-and lipid reactive oxygen species (ROS)-dependent form of
programmed cell death that is distinct from other forms of regulatory cell death at the …
programmed cell death that is distinct from other forms of regulatory cell death at the …
[HTML][HTML] The role of cystine/glutamate antiporter SLC7A11/xCT in the pathophysiology of cancer
N Jyotsana, KT Ta, KE DelGiorno - Frontiers in oncology, 2022 - frontiersin.org
SLC7A11/xCT is an antiporter that mediates the uptake of extracellular cystine in exchange
for glutamate. Cystine is reduced to cysteine, which is a rate-limiting precursor in glutathione …
for glutamate. Cystine is reduced to cysteine, which is a rate-limiting precursor in glutathione …
Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer
SLC7A11-mediated cystine uptake is critical for maintaining redox balance and cell survival.
Here we show that this comes at a significant cost for cancer cells with high levels of …
Here we show that this comes at a significant cost for cancer cells with high levels of …
[HTML][HTML] Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer
Cancer cells often upregulate nutrient transporters to fulfill their increased biosynthetic and
bioenergetic needs, and to maintain redox homeostasis. One nutrient transporter frequently …
bioenergetic needs, and to maintain redox homeostasis. One nutrient transporter frequently …
[HTML][HTML] An overview on the role of relative humidity in airborne transmission of SARS-CoV-2 in indoor environments
A Ahlawat, A Wiedensohler, SK Mishra - Aerosol and Air Quality …, 2020 - aaqr.org
ABSTRACT COVID-19 disease is caused by severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2), which originated in Wuhan, China and spread with an astonishing rate …
2 (SARS-CoV-2), which originated in Wuhan, China and spread with an astonishing rate …