Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications
The prefrontal cortex (PFC) serves as the chief executive officer of the brain, controlling the
highest level cognitive and emotional processes. Its local circuits among glutamatergic …
highest level cognitive and emotional processes. Its local circuits among glutamatergic …
The role of GABAergic signalling in neurodevelopmental disorders
GABAergic inhibition shapes the connectivity, activity and plasticity of the brain. A series of
exciting new discoveries provides compelling evidence that disruptions in a number of key …
exciting new discoveries provides compelling evidence that disruptions in a number of key …
A standardized social preference protocol for measuring social deficits in mouse models of autism
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social
communication deficits and other behavioral abnormalities. The three-chamber social …
communication deficits and other behavioral abnormalities. The three-chamber social …
16p11. 2 copy number variations and neurodevelopmental disorders
Copy number variations (CNVs) of the human 16p11. 2 genetic locus are associated with a
range of neurodevelopmental disorders, including autism spectrum disorder, intellectual …
range of neurodevelopmental disorders, including autism spectrum disorder, intellectual …
[HTML][HTML] Advancing social behavioral neuroscience by integrating ethology and comparative psychology methods through machine learning
Social behavior is naturally occurring in vertebrate species, which holds a strong
evolutionary component and is crucial for the normal development and survival of …
evolutionary component and is crucial for the normal development and survival of …
The molecular pathology of schizophrenia: An overview of existing knowledge and new directions for future research
T Nakamura, A Takata - Molecular Psychiatry, 2023 - nature.com
Despite enormous efforts employing various approaches, the molecular pathology in the
schizophrenia brain remains elusive. On the other hand, the knowledge of the association …
schizophrenia brain remains elusive. On the other hand, the knowledge of the association …
Shank2/3 double knockout-based screening of cortical subregions links the retrosplenial area to the loss of social memory in autism spectrum disorders
D Garrido, S Beretta, S Grabrucker, HF Bauer… - Molecular …, 2022 - nature.com
Members of the Shank protein family are master scaffolds of the postsynaptic architecture
and mutations within the SHANK genes are causally associated with autism spectrum …
and mutations within the SHANK genes are causally associated with autism spectrum …
Cholinergic neurons in the basal forebrain are involved in behavioral abnormalities associated with Cul3 deficiency: role of prefrontal cortex projections in cognitive …
Loss-of-function mutations of the gene Cul3 have been identified as a risk factor for autism-
spectrum disorder (ASD), but the pathogenic mechanisms are not well understood …
spectrum disorder (ASD), but the pathogenic mechanisms are not well understood …
Prefrontal interneurons: populations, pathways, and plasticity supporting typical and disordered cognition in rodent models
Prefrontal cortex (PFC) inhibitory microcircuits regulate the gain and timing of pyramidal
neuron firing, coordinate neural ensemble interactions, and gate local and long-range …
neuron firing, coordinate neural ensemble interactions, and gate local and long-range …
Essential functions of the transcription factor Npas4 in neural circuit development, plasticity, and diseases
J Fu, O Guo, Z Zhen, J Zhen - Frontiers in Neuroscience, 2020 - frontiersin.org
Signaling from the synapse to nucleus is mediated by the integration and propagation of
both membrane potential changes (postsynaptic potentials) and intracellular second …
both membrane potential changes (postsynaptic potentials) and intracellular second …