Vascular Malformations belong to the spectrum of orphan diseases and can involve all
segments of the vascular tree: arteries, capillaries, and veins, and similarly the lymphatic …

The International Society for the Study of Vascular Anomalies (ISSVA) classification is a
comprehensive histology-based scheme that was updated in 2018. It is important for …

Abstract The International Society for the Study of Vascular Anomalies classifies vascular
anomalies into vascular tumors and vascular malformations. Vascular tumors are neoplasms …

In the past, a lack of logical and consistent nomenclature posed a considerable obstacle to
the understanding and diagnosis of vascular lesions. 1 Old classifications were often overly …

Background Polycythemia vera (PV) is a refractory hematological disease that lack of
effective therapy. Chinese traditional medicine Longchai Jiangxue formula (LCJX) has …

Vascular anomalies, both vascular tumors and vascular malformations, can occur in
isolation or as part of syndromes including those which feature phenotypic overgrowth. To …

The overgrowth syndromes related to phosphatidylinositol-4, 5-bisphosphate 3-kinase
(PI3K) are grouped under the concept of PROS (PIK3CA-related overgrowth spectrum). It is …

Extracranial vascular malformations vary greatly and belong to the complex field of orphan
diseases and can involve all segments of the vascular tree: arteries, capillaries, and veins …

Oncogenic RAS variants lead to constitutive overactivation and increased signal
transduction into downstream pathways. They are found as somatic driver events in various …

Papillary intralymphatic angioendothelioma (PILA) is an extremely rare vascular tumor and
its pathogenesis is unknown. Phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic …