Molecular mechanisms of poxvirus evolution

G Brennan, AMM Stoian, H Yu, MJ Rahman… - MBio, 2023 - Am Soc Microbiol
Poxviruses are often thought to evolve relatively slowly because they are double-stranded
DNA pathogens with proofreading polymerases. However, poxviruses have highly …

[HTML][HTML] Monkeypox virus: the changing facets of a zoonotic pathogen

D Forni, R Cagliani, C Molteni, M Clerici… - Infection, Genetics and …, 2022 - Elsevier
In the last five years, the prevalence of monkeypox has been increasing both in the regions
considered endemic for the disease (West and Central Africa) and worldwide. Indeed, in …

Lumpy skin disease: history, current understanding and research gaps in the context of recent geographic expansion

A Mazloum, A Van Schalkwyk, S Babiuk… - Frontiers in …, 2023 - frontiersin.org
Lumpy skin disease is recognized as a transboundary and emerging disease of cattle,
buffaloes and other wild ruminants. Being initially restricted to Africa, and since 1989 the …

Mpox virus: its molecular evolution and potential impact on viral epidemiology

X Yu, H Shi, G Cheng - Viruses, 2023 - mdpi.com
Mpox (previously known as monkeypox) is an infectious viral illness caused by the mpox
virus (MPXV), an orthopoxvirus that belongs to the family Poxviridae. The symptoms of mpox …

Phylogeny and molecular evolution of the first local monkeypox virus cluster in Guangdong Province, China

J Yu, X Zhang, J Liu, L Xiang, S Huang, X Xie… - Nature …, 2023 - nature.com
The first local mpox outbreak in Guangdong Province, China occurred in June 2023.
However, epidemiological data have failed to quickly identify the source and transmission of …

Recombination shapes the 2022 monkeypox (mpox) outbreak

TY Yeh, ZY Hsieh, MC Feehley, PJ Feehley… - Med, 2022 - cell.com
Monkeypox (Mpox) is a global health emergency. Yeh et al. analyze tandem repeats and
linkage disequilibrium in monkeypox virus (MPXV) sequences from the 2022 pandemic to …

CRISPR-mediated rapid arming of poxvirus vectors enables facile generation of the novel immunotherapeutic STINGPOX

JT Whelan, R Singaravelu, F Wang, A Pelin… - Frontiers in …, 2023 - frontiersin.org
Poxvirus vectors represent versatile modalities for engineering novel vaccines and cancer
immunotherapies. In addition to their oncolytic capacity and immunogenic influence, they …

Gene duplication, gene loss, and recombination events with variola virus shaped the complex evolutionary path of historical American horsepox-based smallpox …

ARV Souza, A Brinkmann, J Esparza, A Nitsche… - Mbio, 2023 - Am Soc Microbiol
Vaccinia virus is the active component of all modern smallpox vaccines after the mid-20th
century, but it is uncertain to what extent cowpox, vaccinia, and horsepox viruses were used …

Genomic characterization of the historical smallpox vaccine strain wyeth isolated from a 1971 seed vial

NVG Cruz, MN Luques, TMPP Castiñeiras… - Viruses, 2022 - mdpi.com
The Wyeth strain of vaccinia virus (VACV) produced by Wyeth Pharmaceuticals was
supposedly used to manufacture the old freeze-dried American smallpox vaccine, Dryvax …

Cationic cycloamylose based nucleic acid nanocarriers.

P Prasher, M Sharma, V Agarwal, SK Singh… - Chemico-Biological …, 2024 - Elsevier
Nucleic acid delivery by viral and non-viral methods has been a cornerstone for the
contemporary gene therapy aimed at correcting the defective genes, replacing of the …