Molecular mechanisms of poxvirus evolution
Poxviruses are often thought to evolve relatively slowly because they are double-stranded
DNA pathogens with proofreading polymerases. However, poxviruses have highly …
DNA pathogens with proofreading polymerases. However, poxviruses have highly …
[HTML][HTML] Monkeypox virus: the changing facets of a zoonotic pathogen
In the last five years, the prevalence of monkeypox has been increasing both in the regions
considered endemic for the disease (West and Central Africa) and worldwide. Indeed, in …
considered endemic for the disease (West and Central Africa) and worldwide. Indeed, in …
Lumpy skin disease: history, current understanding and research gaps in the context of recent geographic expansion
Lumpy skin disease is recognized as a transboundary and emerging disease of cattle,
buffaloes and other wild ruminants. Being initially restricted to Africa, and since 1989 the …
buffaloes and other wild ruminants. Being initially restricted to Africa, and since 1989 the …
Mpox virus: its molecular evolution and potential impact on viral epidemiology
X Yu, H Shi, G Cheng - Viruses, 2023 - mdpi.com
Mpox (previously known as monkeypox) is an infectious viral illness caused by the mpox
virus (MPXV), an orthopoxvirus that belongs to the family Poxviridae. The symptoms of mpox …
virus (MPXV), an orthopoxvirus that belongs to the family Poxviridae. The symptoms of mpox …
Phylogeny and molecular evolution of the first local monkeypox virus cluster in Guangdong Province, China
J Yu, X Zhang, J Liu, L Xiang, S Huang, X Xie… - Nature …, 2023 - nature.com
The first local mpox outbreak in Guangdong Province, China occurred in June 2023.
However, epidemiological data have failed to quickly identify the source and transmission of …
However, epidemiological data have failed to quickly identify the source and transmission of …
Recombination shapes the 2022 monkeypox (mpox) outbreak
TY Yeh, ZY Hsieh, MC Feehley, PJ Feehley… - Med, 2022 - cell.com
Monkeypox (Mpox) is a global health emergency. Yeh et al. analyze tandem repeats and
linkage disequilibrium in monkeypox virus (MPXV) sequences from the 2022 pandemic to …
linkage disequilibrium in monkeypox virus (MPXV) sequences from the 2022 pandemic to …
CRISPR-mediated rapid arming of poxvirus vectors enables facile generation of the novel immunotherapeutic STINGPOX
JT Whelan, R Singaravelu, F Wang, A Pelin… - Frontiers in …, 2023 - frontiersin.org
Poxvirus vectors represent versatile modalities for engineering novel vaccines and cancer
immunotherapies. In addition to their oncolytic capacity and immunogenic influence, they …
immunotherapies. In addition to their oncolytic capacity and immunogenic influence, they …
Gene duplication, gene loss, and recombination events with variola virus shaped the complex evolutionary path of historical American horsepox-based smallpox …
ARV Souza, A Brinkmann, J Esparza, A Nitsche… - Mbio, 2023 - Am Soc Microbiol
Vaccinia virus is the active component of all modern smallpox vaccines after the mid-20th
century, but it is uncertain to what extent cowpox, vaccinia, and horsepox viruses were used …
century, but it is uncertain to what extent cowpox, vaccinia, and horsepox viruses were used …
Genomic characterization of the historical smallpox vaccine strain wyeth isolated from a 1971 seed vial
NVG Cruz, MN Luques, TMPP Castiñeiras… - Viruses, 2022 - mdpi.com
The Wyeth strain of vaccinia virus (VACV) produced by Wyeth Pharmaceuticals was
supposedly used to manufacture the old freeze-dried American smallpox vaccine, Dryvax …
supposedly used to manufacture the old freeze-dried American smallpox vaccine, Dryvax …
Cationic cycloamylose based nucleic acid nanocarriers.
Nucleic acid delivery by viral and non-viral methods has been a cornerstone for the
contemporary gene therapy aimed at correcting the defective genes, replacing of the …
contemporary gene therapy aimed at correcting the defective genes, replacing of the …