GABA tone regulation and its cognitive functions in the brain
Abstract γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter released at
GABAergic synapses, mediating fast-acting phasic inhibition. Emerging lines of evidence …
GABAergic synapses, mediating fast-acting phasic inhibition. Emerging lines of evidence …
[HTML][HTML] Inflammation as a central mechanism in Alzheimer's disease
JW Kinney, SM Bemiller, AS Murtishaw… - Alzheimer's & Dementia …, 2018 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized
by cognitive decline and the presence of two core pathologies, amyloid β plaques and …
by cognitive decline and the presence of two core pathologies, amyloid β plaques and …
Physiology of astroglia
A Verkhratsky, M Nedergaard - Physiological reviews, 2018 - journals.physiology.org
Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …
A comprehensive review of monoamine oxidase inhibitors as Anti-Alzheimer's disease agents: A review
Monoamine oxidases (MAO-A and MAO-B) are mammalian flavoenzyme, which catalyze the
oxidative deamination of several neurotransmitters like norepinephrine, dopamine, tyramine …
oxidative deamination of several neurotransmitters like norepinephrine, dopamine, tyramine …
Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and …
UV Mahajan, VR Varma, ME Griswold… - PLoS …, 2020 - journals.plos.org
Background There is growing evidence that Alzheimer disease (AD) is a pervasive
metabolic disorder with dysregulation in multiple biochemical pathways underlying its …
metabolic disorder with dysregulation in multiple biochemical pathways underlying its …
Neuron-glia interactions in neurodevelopmental disorders
YS Kim, J Choi, BE Yoon - Cells, 2020 - mdpi.com
Recent studies have revealed synaptic dysfunction to be a hallmark of various psychiatric
diseases, and that glial cells participate in synapse formation, development, and plasticity …
diseases, and that glial cells participate in synapse formation, development, and plasticity …
Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis
Monoamine oxidase (MAO) is believed to mediate the degradation of monoamine
neurotransmitters, including dopamine, in the brain. Between the two types of MAO, MAO-B …
neurotransmitters, including dopamine, in the brain. Between the two types of MAO, MAO-B …
Chloride transporters controlling neuronal excitability
JC Pressey, M de Saint-Rome… - Physiological …, 2023 - journals.physiology.org
Synaptic inhibition plays a crucial role in regulating neuronal excitability, which is the
foundation of nervous system function. This inhibition is largely mediated by the …
foundation of nervous system function. This inhibition is largely mediated by the …
Astrocytes: GABAceptive and GABAergic cells in the brain
Astrocytes, the most numerous glial cells in the brain, play an important role in preserving
normal neural functions and mediating the pathogenesis of neurological disorders. Recent …
normal neural functions and mediating the pathogenesis of neurological disorders. Recent …
New insights on astrocyte ion channels: critical for homeostasis and neuron-glia signaling
ML Olsen, BS Khakh, SN Skatchkov… - Journal of …, 2015 - Soc Neuroscience
Initial biophysical studies on glial cells nearly 50 years ago identified these cells as being
electrically silent. These first studies also demonstrated a large K+ conductance, which led …
electrically silent. These first studies also demonstrated a large K+ conductance, which led …