Roles of JAK2 in aging, inflammation, hematopoiesis and malignant transformation

F Perner, C Perner, T Ernst, FH Heidel - Cells, 2019 - mdpi.com
Clonal alterations in hematopoietic cells occur during aging and are often associated with
the establishment of a subclinical inflammatory environment. Several age-related conditions …

A Broad Overview of Signaling in Ph-Negative Classic Myeloproliferative Neoplasms

A Guijarro-Hernández, JL Vizmanos - Cancers, 2021 - mdpi.com
Simple Summary There is growing evidence that Ph-negative myeloproliferative neoplasms
are disorders in which multiple signaling pathways are significantly disturbed. The …

A randomized double-blind trial of 3 aspirin regimens to optimize antiplatelet therapy in essential thrombocythemia

B Rocca, A Tosetto, S Betti, D Soldati… - Blood, The Journal …, 2020 - ashpublications.org
Essential thrombocythemia (ET) is characterized by abnormal megakaryopoiesis and
enhanced thrombotic risk. Once-daily low-dose aspirin is the recommended antithrombotic …

[HTML][HTML] Baseline factors associated with response to ruxolitinib: an independent study on 408 patients with myelofibrosis

F Palandri, GA Palumbo, M Bonifacio, M Tiribelli… - Oncotarget, 2017 - ncbi.nlm.nih.gov
In patients with Myelofibrosis (MF) treated with ruxolitinib (RUX), the response is
unpredictable at therapy start. We retrospectively evaluated the impact of clinical/laboratory …

Tamoxifen for the treatment of myeloproliferative neoplasms: A Phase II clinical trial and exploratory analysis

Z Fang, G Corbizi Fattori, T McKerrell… - Nature …, 2023 - nature.com
Current therapies for myeloproliferative neoplasms (MPNs) improve symptoms but have
limited effect on tumor size. In preclinical studies, tamoxifen restored normal apoptosis in …

Sex determines the presentation and outcomes in MPN and is related to sex-specific differences in the mutational burden

T Karantanos, S Chaturvedi, EM Braunstein… - Blood …, 2020 - ashpublications.org
The factors underlying the variable presentation and clinical course of myeloproliferative
neoplasms (MPNs) remain unclear. The aim of this study was to evaluate the independent …

Determinants of patient‐reported xerostomia among long‐term oropharyngeal cancer survivors

P Aggarwal, KA Hutcheson, AS Garden, FE Mott, C Lu… - Cancer, 2021 - Wiley Online Library
Background This study was conducted to identify clinicodemographic risk factors for
xerostomia among long‐term oropharyngeal cancer (OPC) survivors. Methods This cross …

Heterogeneity in myeloproliferative neoplasms: Causes and consequences

J O'Sullivan, AJ Mead - Advances in biological regulation, 2019 - Elsevier
Myeloproliferative neoplasms (MPNs) are haematopoietic stem cell-derived clonal disorders
characterised by proliferation of some or all myeloid lineages, depending on the subtype …

Determinants of cancer-related fatigue among cancer patients: a systematic review

F DSilva, P Singh, A Javeth - Journal of Palliative Care, 2023 - journals.sagepub.com
Objectives: This systematic review aims to assess and explore various determinants of
cancer-related fatigue. Methods: A systematic search of various determinants of Cancer …

Polycythemia vera-associated complications: pathogenesis, clinical manifestations, and effects on outcomes

D Cuthbert, BL Stein - Journal of Blood Medicine, 2019 - Taylor & Francis
Polycythemia vera is a Philadelphia-negative chronic myeloproliferative neoplasm,
characterized by erythrocytosis, which is unique, compared to essential thrombocytosis and …