Sex differences in neuronal systems function and behaviour: beyond a single diagnosis in autism spectrum disorders

OOF Williams, M Coppolino, ML Perreault - Translational Psychiatry, 2021 - nature.com
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that is
associated with functional brain alterations that underlie the expression of behaviour. Males …

Prefrontal interneurons: populations, pathways, and plasticity supporting typical and disordered cognition in rodent models

DA Kupferschmidt, KA Cummings, ME Joffe… - Journal of …, 2022 - Soc Neuroscience
Prefrontal cortex (PFC) inhibitory microcircuits regulate the gain and timing of pyramidal
neuron firing, coordinate neural ensemble interactions, and gate local and long-range …

Top-down control of hippocampal signal-to-noise by prefrontal long-range inhibition

R Malik, Y Li, S Schamiloglu, VS Sohal - Cell, 2022 - cell.com
Prefrontal cortex (PFC) is postulated to exert" top-down control" on information processing
throughout the brain to promote specific behaviors. However, pathways mediating top-down …

The medial septum controls hippocampal supra-theta oscillations

B Király, A Domonkos, M Jelitai… - nature …, 2023 - nature.com
Hippocampal theta oscillations orchestrate faster beta-to-gamma oscillations facilitating the
segmentation of neural representations during navigation and episodic memory. Supra …

Autism risk gene POGZ promotes chromatin accessibility and expression of clustered synaptic genes

E Markenscoff-Papadimitriou, F Binyameen, S Whalen… - Cell reports, 2021 - cell.com
Deleterious genetic variants in POGZ, which encodes the chromatin regulator Pogo
Transposable Element with ZNF Domain protein, are strongly associated with autism …

[HTML][HTML] Understanding autism spectrum disorders with animal models: applications, insights, and perspectives

Z Li, YX Zhu, LJ Gu, Y Cheng - Zoological research, 2021 - ncbi.nlm.nih.gov
Autism spectrum disorder (ASD) is typically characterized by common deficits in social skills
and repetitive/stereotyped behaviors. It is widely accepted that genetic and environmental …

Activity of ventral hippocampal parvalbumin interneurons during anxiety

E Volitaki, T Forro, K Li, T Nevian, S Ciocchi - Cell reports, 2024 - cell.com
Anxiety plays a key role in guiding behavior in response to potential threats. Anxiety is
mediated by the activation of pyramidal neurons in the ventral hippocampus (vH), whose …

The role of aberrant neural oscillations in the hippocampal-medial prefrontal cortex circuit in neurodevelopmental and neurological disorders

N Shing, MC Walker, P Chang - Neurobiology of Learning and Memory, 2022 - Elsevier
The hippocampus (HPC) and medial prefrontal cortex (mPFC) have well-established roles in
cognition, emotion, and sensory processing. In recent years, interests have shifted towards …

Neuronal oscillations: early biomarkers of psychiatric disease?

A Günther, IL Hanganu-Opatz - Frontiers in Behavioral Neuroscience, 2022 - frontiersin.org
Our understanding of the environmental and genetic factors contributing to the wide
spectrum of neuropsychiatric disorders has significantly increased in recent years …

Amygdala-hippocampus somatostatin interneuron beta-synchrony underlies a cross-species biomarker of emotional state

AD Jackson, JL Cohen, AJ Phensy, EF Chang… - Neuron, 2024 - cell.com
Emotional responses arise from limbic circuits including the hippocampus and amygdala. In
the human brain, beta-frequency communication between these structures correlates with …