[HTML][HTML] Efficacy of acetylcholinesterase inhibitors in Alzheimer's disease
G Marucci, M Buccioni, D Dal Ben, C Lambertucci… - …, 2021 - Elsevier
Abstract Alzheimer's disease (AD), the most common cause of adult-onset dementia is
characterized by a progressive decline of cognitive functions accompanied by behavioral …
characterized by a progressive decline of cognitive functions accompanied by behavioral …
Mitochondrial dysfunction, oxidative stress, neuroinflammation, and metabolic alterations in the progression of Alzheimer's disease: A meta-analysis of in vivo …
Accumulating evidence demonstrates that metabolic changes in the brain associated with
neuroinflammation, oxidative stress, and mitochondrial dysfunction play an important role in …
neuroinflammation, oxidative stress, and mitochondrial dysfunction play an important role in …
Current aspects of the endocannabinoid system and targeted THC and CBD phytocannabinoids as potential therapeutics for Parkinson's and Alzheimer's diseases: a …
Neurodegeneration leading to Parkinson's disease (PD) and Alzheimer's disease (AD) has
become a major health burden globally. Current treatments mainly target controlling …
become a major health burden globally. Current treatments mainly target controlling …
Beyond neurotransmission: acetylcholine in immunity and inflammation
MA Cox, C Bassi, ME Saunders… - Journal of internal …, 2020 - Wiley Online Library
Acetylcholine (ACh) is best known as a neurotransmitter and was the first such molecule
identified. ACh signalling in the neuronal cholinergic system has long been known to …
identified. ACh signalling in the neuronal cholinergic system has long been known to …
Protective effects of flavonoids against Alzheimer's disease: pathological hypothesis, potential targets, and structure–activity relationship
J Li, M Sun, X Cui, C Li - International Journal of Molecular Sciences, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease with high morbidity and mortality,
for which there is no available cure. Currently, it is generally believed that AD is a disease …
for which there is no available cure. Currently, it is generally believed that AD is a disease …
Probing 4-(diethylamino)-salicylaldehyde-based thiosemicarbazones as multi-target directed ligands against cholinesterases, carbonic anhydrases and α-glycosidase …
With the fading of 'one drug-one target'approach, Multi-Target-Directed Ligands (MTDL) has
become a central idea in modern Medicinal Chemistry. The present study aimed to design …
become a central idea in modern Medicinal Chemistry. The present study aimed to design …
Bornyl acetate: A promising agent in phytomedicine for inflammation and immune modulation
Z Zhao, Y Sun, X Ruan - Phytomedicine, 2023 - Elsevier
Background Bornyl acetate (BA), as a bicyclic monoterpene, is an active volatile component
widely found in plants across the globe. BA can be used as essence and food flavor agent …
widely found in plants across the globe. BA can be used as essence and food flavor agent …
Biomarkers associated with the pathogenesis of Alzheimer's disease
H Wang, M Sun, W Li, X Liu, M Zhu… - Frontiers in Cellular …, 2023 - frontiersin.org
Alzheimer's disease (AD) is a progressive degenerative neurological illness with insidious
onset. Due to the complexity of the pathogenesis of AD and different pathological changes …
onset. Due to the complexity of the pathogenesis of AD and different pathological changes …
Design, synthesis, biological evaluation, and docking study of novel dual-acting thiazole-pyridiniums inhibiting acetylcholinesterase and β-amyloid aggregation for …
New compounds containing thiazole and pyridinium moieties were designed and
synthesized. The potency of the synthesized compounds as selective inhibitors of …
synthesized. The potency of the synthesized compounds as selective inhibitors of …
Multitargeted Molecular Docking and Dynamic Simulation Studies of Bioactive Compounds from Rosmarinus officinalis against Alzheimer's Disease
Alzheimer's disease (AD) has been associated with the hallmark features of cholinergic
dysfunction, amyloid beta (Aβ) aggregation and impaired synaptic transmission, which …
dysfunction, amyloid beta (Aβ) aggregation and impaired synaptic transmission, which …