Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy

JA Gorter, EA van Vliet, E Aronica, T Breit… - Journal of …, 2006 - Soc Neuroscience
To get insight into the mechanisms that may lead to progression of temporal lobe epilepsy,
we investigated gene expression during epileptogenesis in the rat. RNA was obtained from …

Blood‐brain barrier breakdown following traumatic brain injury: a possible role in posttraumatic epilepsy

O Tomkins, A Feintuch, M Benifla… - Cardiovascular …, 2011 - Wiley Online Library
Recent animal experiments indicate a critical role for opening of the blood‐brain barrier
(BBB) in the pathogenesis of post‐traumatic epilepsy (PTE). This study aimed to investigate …

Blood–brain barrier disruption in post-traumatic epilepsy

O Tomkins, I Shelef, I Kaizerman, A Eliushin… - Journal of Neurology …, 2008 - jnnp.bmj.com
Background: Traumatic brain injury (TBI) is an important cause of focal epilepsy. Animal
experiments indicate that disruption of the blood–brain barrier (BBB) plays a critical role in …

Spreading depolarizations and late secondary insults after traumatic brain injury

JA Hartings, AJ Strong, M Fabricius… - Journal of …, 2009 - liebertpub.com
Here we investigated the incidence of cortical spreading depolarizations (spreading
depression and peri-infarct depolarization) after traumatic brain injury (TBI) and their …

Delayed secondary phase of peri-infarct depolarizations after focal cerebral ischemia: relation to infarct growth and neuroprotection

JA Hartings, ML Rolli, XCM Lu… - Journal of …, 2003 - Soc Neuroscience
In focal cerebral ischemia, peri-infarct depolarizations (PIDs) cause an expansion of core-
infarcted tissue into adjacent penumbral regions of reversible injury and have been shown …

Susceptibility of immature and adult brains to seizure effects

SR Haut, J Veliškova, SL Moshé - The Lancet Neurology, 2004 - thelancet.com
The extent that status epilepticus (SE), but also brief seizures, affects neuronal structure and
function has been the subject of much clinical and experimental research. There is a …

Perturbation of brain oscillations after ischemic stroke: a potential biomarker for post-stroke function and therapy

G Rabiller, JW He, Y Nishijima, A Wong… - International journal of …, 2015 - mdpi.com
Brain waves resonate from the generators of electrical current and propagate across brain
regions with oscillation frequencies ranging from 0.05 to 500 Hz. The commonly observed …

Characterization of a new rat model of penetrating ballistic brain injury

AJ Williams, JA Hartings, XCM Lu, ML Rolli… - Journal of …, 2005 - liebertpub.com
Penetrating brain injury (PBI) is a leading cause of mortality and morbidity in modern warfare
and accounts for a significant number of traumatic brain injuries worldwide. Here we …

Post-stroke seizures are clinically underestimated

C Bentes, H Martins, AR Peralta, C Casimiro… - Journal of …, 2017 - Springer
Cerebrovascular disease is the leading cause of epilepsy in adults, although post-stroke
seizures reported frequency is variable and few studies used EEG in their identification. To …

Epilepsy in the elderly

IE Leppik, AK Birnbaum - Annals of the New York Academy of …, 2010 - Wiley Online Library
The elderly, often defined as those 65 years or older, are the most rapidly growing segment
of the population, and onset of epilepsy is higher in this age group than in any other. This …