Post-stroke gaseous hypothermia increases vascular density but not neurogenesis in the ischemic penumbra of aged rats

RE Sandu, A Uzoni, O Ciobanu… - Restorative …, 2016 - content.iospress.com
Purpose: In aged humans, stroke is a major cause of disability for which no neuroprotective
measures are available. In animal studies of focal ischemia, short-term hypothermia often …

Association between seizures after ischemic stroke and stroke outcome: a systematic review and meta-analysis

T Xu, S Ou, X Liu, X Yu, J Yuan, H Huang, Y Chen - Medicine, 2016 - journals.lww.com
Association between seizures after ischemic stroke and strok... : Medicine Association between
seizures after ischemic stroke and stroke outcome: A systematic review and meta-analysis …

Seizure activity occurs in the collagenase but not the blood infusion model of striatal hemorrhagic stroke in rats

AC Klahr, CT Dickson, F Colbourne - Translational stroke research, 2015 - Springer
Seizures are a frequent complication of brain injury, including intracerebral hemorrhage
(ICH), where seizures occur in about a third of patients. Rodents are used to study …

Intrahippocampal injection of endothelin‐1 in immature rats results in neuronal death, development of epilepsy and behavioral abnormalities later in life

A Mátéffyová, J Otáhal, G Tsenov… - European Journal of …, 2006 - Wiley Online Library
The direct injection of endothelin‐1 (ET‐1) into brain parenchyma was recently suggested
as a suitable model of stroke. The present study was designed to assess whether …

Electrocortical pathology in a rat model of penetrating ballistic-like brain injury

XCM Lu, JA Hartings, Y Si, A Balbir, Y Cao… - Journal of …, 2011 - liebertpub.com
Traumatic brain injury (TBI) causes severe disruption of cerebral electrical activity and
electroencephalography (EEG) is emerging as a standard tool to monitor TBI patients in the …

Twenty-four hours hypothermia has temporary efficacy in reducing brain infarction and inflammation in aged rats

RE Sandu, AM Buga, AT Balseanu, M Moldovan… - Neurobiology of …, 2016 - Elsevier
Stroke is a major cause of disability for which no neuroprotective measures are available.
Age is the principal nonmodifiable risk factor for this disease. Previously, we reported that …

Epilepsy and aging

RJ Kotloski, J Dowding, BP Hermann… - Handbook of Clinical …, 2019 - Elsevier
The intersection of epilepsy and aging has broad, significant implications. Substantial
increases in seizures occur both in the elderly population, who are at a higher risk of …

NNZ-2566, a glypromate analog, attenuates brain ischemia-induced non-convulsive seizures in rats

XCM Lu, Y Si, AJ Williams, JA Hartings… - Journal of Cerebral …, 2009 - journals.sagepub.com
Ischemic and traumatic brain injuries often induce non-convulsive seizures (NCSs), which
likely contribute to the worsening of neurological outcomes. Here, we evaluated the effect of …

The antiepileptic drug levetiracetam suppresses non-convulsive seizure activity and reduces ischemic brain damage in rats subjected to permanent middle cerebral …

O Cuomo, V Rispoli, A Leo, GB Politi, A Vinciguerra… - PLoS …, 2013 - journals.plos.org
The antiepileptic drug Levetiracetam (Lev) has neuroprotective properties in experimental
stroke, cerebral hemorrhage and neurotrauma. In these conditions, non-convulsive seizures …

Periodic lateralized epileptiform discharges and afterdischarges: common dynamic mechanisms

GP Kalamangalam, JD Slater - Journal of Clinical …, 2015 - journals.lww.com
Purpose: No neurophysiological hypothesis currently exists addressing how and why
periodic lateralized epileptiform discharges (PLEDs) arise in certain types of brain disease …