Heart failure with preserved ejection fraction (HFpEF) represents one of the greatest
challenges facing cardiovascular medicine today. Despite being the most common form of …

The vascular cellular adhesion molecule-1 (VCAM-1) is a protein that canonically
participates in the adhesion and transmigration of leukocytes to the interstitium during …

Human cardiac organoids hold remarkable potential for cardiovascular disease modeling
and human pluripotent stem cell–derived cardiomyocyte (hPSC-CM) transplantation. Here …

Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although
recent advances in cell-based models, including human-induced pluripotent stem cell …

Rationale: Cardiac function is under exquisite intrinsic cardiac neural control. Neuroablative
techniques to modulate control of cardiac function are currently being studied in patients …

Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide, accounting
for 10% to 15% of all deaths. Although most arrhythmias are due to acquired heart disease …

Background: ZFHX3 (zinc finger homeobox 3), a gene that encodes a large transcription
factor, is at the second-most significantly associated locus with atrial fibrillation (AF), but its …

Atrial fibrillation is very common among the elderly and/or obese. While myocardial fibrosis
is associated with atrial fibrillation, the exact mechanisms within atrial myocytes and …

Aims Atrial fibrillation (AF) is associated with tachycardia-induced cellular electrophysiology
alterations which promote AF chronification and treatment resistance. Development of novel …

Cardiac arrhythmias are a major cause of death and disability. A large number of
experimental cell and animal models have been developed to study arrhythmogenic …