Background The standard protocol to achieve haemostasis during total hip arthroplasty
(THA) is uncertain. Tranexamic acid plus diluted epinephrine (DEP) and tranexamic acid …

What is known and objective This study was performed to compare the efficacy and safety of
combined administration of intravenous (IV) and intra‐articular (IA) tranexamic acid (TXA) …

Background: Tranexamic acid (TXA) is an antifibrinolytic drug. Topical administration of TXA
during total knee arthroplasty (TKA) is favored for certain patients because of concerns …

Background Tranexamic acid (TXA) administration to reduce postoperative blood loss and
transfusion is a well-established practice for total knee arthroplasty (TKA) and total hip …

Tranexamic acid (TXA) is a lysine analog that exhibits an anti-fibrinolytic effect by directly
preventing the activation of plasminogen as well as inhibiting activated plasmin from …

Background The optimal dosage and administration approach of tranexamic acid (TXA) in
primary total knee arthroplasty (TKA) remains controversial. In light of recently published 14 …

Aim The ideal route of tranexamic acid (TXA) administration in total hip arthroplasty (THA) or
total knee arthroplasty (TKA) remains controversial. This study aims to identify the optima …

Background: Tranexamic acid (TXA) was conducive in total knee arthroplasty (TKA) to
reduce blood loss and transfusion demand. The purpose of this meta-analysis was to assess …

Results. Transfusion rate in group 1 was found to be 15%, compared to 44% in group 2 (p-
value= 0.015). In transfused patients the mean received blood units were 1.2 (SD= 0.44) in …

Background Hip and knee replacement surgery is a well‐established means of improving
quality of life, but is associated with a significant risk of bleeding. One‐third of people are …