Long non-coding RNA (lncRNA) roles in cell biology, neurodevelopment and neurological disorders
V Aliperti, J Skonieczna, A Cerase - Non-coding RNA, 2021 - mdpi.com
Development is a complex process regulated both by genetic and epigenetic and
environmental clues. Recently, long non-coding RNAs (lncRNAs) have emerged as key …
environmental clues. Recently, long non-coding RNAs (lncRNAs) have emerged as key …
Wnt/β-catenin-dependent transcription in autism spectrum disorders
MO Caracci, ME Avila… - Frontiers in molecular …, 2021 - frontiersin.org
Autism spectrum disorders (ASD) is a heterogeneous group of neurodevelopmental
disorders characterized by synaptic dysfunction and defects in dendritic spine morphology …
disorders characterized by synaptic dysfunction and defects in dendritic spine morphology …
Epilepsy in Angelman syndrome: A scoping review
D Samanta - Brain and Development, 2021 - Elsevier
Angelman Syndrome (AS) is characterized by severe developmental delays including
marked speech impairment, movement abnormalities (ataxia, tremor), and unique behaviors …
marked speech impairment, movement abnormalities (ataxia, tremor), and unique behaviors …
[HTML][HTML] Autism-linked UBE3A gain-of-function mutation causes interneuron and behavioral phenotypes when inherited maternally or paternally in mice
The E3 ubiquitin ligase Ube3a is biallelically expressed in neural progenitors and glial cells,
suggesting that UBE3A gain-of-function mutations might cause neurodevelopmental …
suggesting that UBE3A gain-of-function mutations might cause neurodevelopmental …
Epilepsy subtype-specific copy number burden observed in a genome-wide study of 17 458 subjects
Cytogenic testing is routinely applied in most neurological centres for severe paediatric
epilepsies. However, which characteristics of copy number variants (CNVs) confer most …
epilepsies. However, which characteristics of copy number variants (CNVs) confer most …
E3 ligases: a potential multi-drug target for different types of cancers and neurological disorders
KM Saravanan, M Kannan, P Meera… - Future Medicinal …, 2022 - Taylor & Francis
Ubiquitylation is a posttranslational modification of proteins that is necessary for a variety of
cellular processes. E1 ubiquitin activating enzyme, E2 ubiquitin conjugating enzyme, and E3 …
cellular processes. E1 ubiquitin activating enzyme, E2 ubiquitin conjugating enzyme, and E3 …
Autism spectrum disorder: signaling pathways and prospective therapeutic targets
J Baranova, G Dragunas, MCS Botellho… - Cellular and molecular …, 2021 - Springer
Abstract The Autism Spectrum Disorder (ASD) consists of a prevalent and heterogeneous
group of neurodevelopmental diseases representing a severe burden to affected individuals …
group of neurodevelopmental diseases representing a severe burden to affected individuals …
HPV E6 inhibits E6AP to regulate epithelial homeostasis by modulating keratinocyte differentiation commitment and YAP1 activation
W Yin, N Egawa, K Zheng, H Griffin, P Tian… - PLoS …, 2023 - journals.plos.org
Human papillomaviruses (HPV) cause persistent infections by modulating epithelial
homeostasis in cells of the infected basal layer. Using FUCCI and cell-cell competition …
homeostasis in cells of the infected basal layer. Using FUCCI and cell-cell competition …
Dysregulation of multiple signaling neurodevelopmental pathways during embryogenesis: a possible cause of autism spectrum disorder
Understanding the autistic brain and the involvement of genetic, non-genetic, and numerous
signaling pathways in the etiology and pathophysiology of autism spectrum disorder (ASD) …
signaling pathways in the etiology and pathophysiology of autism spectrum disorder (ASD) …
Angelman syndrome: a journey through the brain
Angelman syndrome (AS) is an incurable neurodevelopmental disease caused by loss of
function of the maternally inherited UBE3A gene. AS is characterized by a defined set of …
function of the maternally inherited UBE3A gene. AS is characterized by a defined set of …