UBE3A is a gene responsible for the pathogenesis of Angelman syndrome (AS), a
neurodevelopmental disorder characterized by symptoms such as intellectual disability …

Introduction: Angelman syndrome (AS) is a neurodevelopmental disorder caused by
deficiency of maternally inherited UBE3A, an ubiquitin E3 ligase. Despite recent progress in …

Angelman syndrome (AS, MIM 105830) is a rare neurodevelopmental disorder affecting 1:
10–20,000 children. Patients show moderate to severe intellectual disability, ataxia and …

Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by a loss of the
maternally inherited UBE3A; the paternal UBE3A is silenced in neurons by a mechanism …

Published reports from the CDC's Autism and Development Disabilities Monitoring Networks
have shown that an average of 1 in every 44 (2.3%) 8-year-old children were estimated to …

Background Rett syndrome (RTT) is a neurodevelopmental disorder caused mostly by
disruptions in the MECP2 gene. MECP2-null mice show imbalances in neuronal excitability …

Angelman syndrome (AS) is a neurogenetic disorder involving ataxia and motor dysfunction,
resulting from the absence of the maternally inherited functional Ube3a protein in neurons …

ABSTRACT Introduction Approximately 80–90% of patients with Angelman syndrome (AS)
develop childhood-onset intractable seizures with major negative impact on the quality of …

Angelman syndrome is a rare neurodevelopmental disorder caused by a mutation in the
maternal allele of the gene Ube3a. The primary symptoms of Angelman syndrome are …

Highlights•Binding sites on GABA A receptors have been located for steroids.•Zolpidem can
induce sleep by inhibiting histamine neurons.•GABA A receptors in the MPTA induce …