Highlights•Binding sites on GABA A receptors have been located for steroids.•Zolpidem can
induce sleep by inhibiting histamine neurons.•GABA A receptors in the MPTA induce …

Abstract NSI-189 Phosphate,(4-benzylpiperazin-1-yl)-[2-(3-methyl-butylamino) pyridin-3-yl]
methanone is a new chemical entity under development for the treatment of MDD, based …

Angelman syndrome (AS) is a rare neurodevelopmental disorder characterized by severe
mental retardation, absence of speech, abnormal motor coordination, abnormal EEG, and …

Major histocompatibility complex class I (MHCI) is an important immune protein that is
expressed in various brain regions, with its deficiency leading to extensive synaptic …

Changes in UBE3A expression levels in neurons can cause neurogenetic disorders ranging
from Angelman syndrome (AS)(decreased levels) to autism (increased levels). Here we …

Introduction Epilepsy is one of the main clinical problems in Angelman syndrome (AS).
Seizures typically start in early childhood then decrease or are often alleviated by young …

Angelman syndrome (AS) is a genetic neurodevelopmental disorder in which cerebellar
functioning impairment has been documented despite the absence of gross structural …

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with a strong
genetic component. To date, several hundred different genetic mutations have been …

Background Angelman syndrome (AS) is a genetic neurodevelopmental disorder caused by
the loss of function of the UBE3A protein in the brain. In a previous study, we showed that …

Ataxia is the predominant clinical manifestation of cerebellar dysfunction. Mutations in the
human CACNA1A gene, encoding the pore-forming α 1 subunit of Ca V 2.1 (P/Q-type) …