The beam walk is widely used to study coordination and balance in rodents. While the task
has ethological validity, the main endpoints of foot slip counts and time to cross are prone to …

GABA is a predominant inhibitory neurotransmitter in the CNS. Released GABA is removed
from the synaptic cleft by two GABA transporters (GATs), GAT-1 and GAT-3, and their …

THIP (gaboxadol), a superagonist of the δ subunit-containing extrasynaptic GABAA
receptors, produces persistent neuroplasticity in dopamine (DA) neurons of the ventral …

We recently generated a novel Angelman syndrome (AS) rat model with a complete Ube3a
gene deletion, that recapitulates the loss of UBE3A protein and shows cognitive and EEG …

Centenarians provide a unique lens through which to study longevity, healthy aging, and
resiliency. Moreover, models of human aging and resilience to disease that allow for the …

Insights into mechanisms of neurogenetic diseases can inspire precision medicine
approaches, potentially paving the way for more targeted and effective treatments in the …

Background Sensory processing deficits are common in individuals with
neurodevelopmental disorders. One hypothesis is that deficits may be more detectable in …

Angelman Syndrome (AS) is a severe neurodevelopmental disorder, caused by the
neuronal absence of the ubiquitin protein ligase E3A (UBE3A). UBE3A promotes ubiquitin …

Methods of treating developmental disorders such as Angelman syndrome, Fragile X
syndrome, Fragile X-associated tremor/ataxia syndrome (FXTAS), Autistic Spectrum …

Background Angelman syndrome (AS) is neurodevelopmental disorder, causal gene of
which is maternally expressed UBE3A. A majority of patients results from the large deletion …