The catastrophic system failure in amyotrophic lateral sclerosis is characterized by
progressive neurodegeneration within the corticospinal tracts, brainstem nuclei and spinal …

Background Amyotrophic lateral sclerosis (ALS) is a fatal, rapidly progressive
neurodegenerative disease that mainly affects the motor system. A number of potentially …

Spatial normalization of diffusion tensor images plays a key role in voxel-based analysis of
white matter (WM) group differences. Currently, it has been achieved using low-dimensional …

Motoneuron disease is a term encompassing three phenotypes defined largely by the
balance of upper versus lower motoneuron involvement, namely amyotrophic lateral …

Background Amyotrophic lateral sclerosis (ALS) is a fatal disorder caused by the
progressive degeneration of motoneurons in brain and spinal cord. Despite identification of …

OBJECTIVE: To use deuterium-substituted [11C](l)-deprenyl PET to depict astrocytosis in
vivo in patients with amyotrophic lateral sclerosis (ALS). BACKGROUND: In human brain …

Voxel‐based analyses (VBA) are increasingly being used to detect white matter
abnormalities with diffusion tensor imaging (DTI) in different types of pathologies. However …

The statistical reliability of diffusion property measurements was evaluated in ten healthy
subjects using deterministic fiber tracking to localize tracts affected in motor neuron disease …

Motor neuron diseases (MNDs) are a debilitating subset of diseases, which result in
progressive neuronal destruction and eventual loss of voluntary muscular function. These …

ABSTRACT PURPOSE The purpose of the present retrospective study was to evaluate the
sensitivity of susceptibility‐weighted imaging (SWI) compared to conventional spin‐echo T2 …