Loss-of-function defects in DNA mismatch repair (MMR), which manifest as high levels of
microsatellite instability (MSI), occur in approximately 15% of all colorectal carcinomas …

The presence of increased tumor-infiltrating lymphocytes (TILs) is established as a positive
prognostic factor in many malignancies including colorectal carcinoma (CRC). However …

Background The selection of patients for genetic testing to rule out Lynch syndrome is
currently based on fulfilment of at least one of the revised Bethesda criteria followed by …

Reflex mismatch repair immunohistochemistry (MMR IHC) testing for MLH1, PMS2, MSH2
and MSH6 is used to screen for Lynch syndrome. Recently MMR-deficiency (MMRd) has …

BACKGROUND & AIMS: Lymphoepithelioma-like carcinoma (LELC) is a rare subtype of
gastric carcinoma (GC) with a better survival rate than other GCs; most cases of LELC are …

Context.—About 15% of colorectal cancers are characterized by genomic microsatellite
instability, and of these, about 1 in 5 (2%–4% overall) are due to Lynch syndrome, a …

Lynch syndrome (hereditary nonpolyposis colon cancer) and adenomatous polyposis
syndromes frequently have overlapping clinical features. Current approaches for molecular …

Colorectal Cancer (CRC) is the third most prevalent cancer in men and women. Up to 15%
of CRCs display microsatellite instability (MSI). MSI is reflective of a deficient mismatch …

It has been controversial that men carrying a DNA mismatch repair (MMR) gene mutation
(Lynch syndrome) are at heightened risk of prostate cancer given that an increased risk is …

Prediction of prognosis in colorectal cancer is vital for the choice of therapeutic options.
Histopathological factors remain paramount in this respect. Factors such as tumor size …