Administration of cisplatin, a common chemotherapeutic drug, has an inevitable side effect
of sensorineural hearing loss. The main etiologies are stria vascularis injury, spiral ganglion …

Effective administration of traditional cytotoxic chemotherapy is often limited by off-target
toxicities. This clinical dilemma is epitomized by cisplatin, a platinating agent, which has …

Tinnitus is unusual for such a common symptom in that there are few treatment options and
those that are available are aimed at reducing the impact rather than specifically addressing …

Exome sequencing has been commonly used to characterize rare diseases by selecting
multiplex families or singletons with an extreme phenotype (EP) and searching for rare …

Tinnitus, a phantom perception of sound in the absence of any external sound source, is a
prevalent health condition often accompanied by psychiatric comorbidities. Recent genome …

Age-related hearing impairment (ARHI) is the most common sensory disorder in older
adults. We conducted a genome-wide association meta-analysis of 121,934 ARHI cases …

There is increasing evidence of associations between the presence of temporomandibular
joint (TMJ) disorders and tinnitus. It has been recently proposed that tinnitus patients with …

Importance No effective treatments are currently available for severe tinnitus, which affects
1% of the population and lowers the quality of life. The factors that contribute to the transition …

Background tinnitus is a heterogeneous condition associated with audiological and/or
mental disorders. Chronic, severe tinnitus is reported in 1% of the population and it shows a …

Tinnitus can be a burdensome condition on both individual and societal levels. Many
aspects of this condition remain elusive, including its underlying mechanisms, ultimately …