CC motif ligand 2 (CCL2), also known as monocytic chemotactic protein 1 (MCP-1), is an
integral chemotactic factor which recruits macrophages for the immune response. Together …

Exosomes are a subset of extracellular vesicles with an average diameter of~ 100nm.
Exosomes are released by all cells through an endosome-dependent pathway and carry …

Background The maternal immune system needs to tolerate the semi-allogeneic fetus in
pregnancy. The adaptation occurs locally at the maternal–fetal interface as well as …

Embryo–endometrial communication plays a critical role in embryo implantation and the
establishment of a successful pregnancy. Successful pregnancy outcomes involve maternal …

The N6-methyladenosine (m6A) RNA modification regulates the expression of genes
associated with various biological and pathological processes, including spontaneous …

Embryo implantation failure and spontaneous abortions represent the main causes of
infertility in developed countries. Unfortunately, incomplete knowledge of the multiple factors …

Recurrent miscarriage (RM) is a chronic, heterogeneous autoimmune disease that has
serious social and personal consequences. No valid and reliable diagnostic markers or …

Abstract T-cell immunoglobulin mucin-3 (Tim-3) plays roles in the functional regulation of
both adaptive and innate immune cells and is greatly involved in many diseases. However …

As the soil of life, the composition and shaping process of the immune microenvironment of
the uterus is worth exploring. Macrophages, indispensable constituents of the innate …

Macrophages are highly diverse cells and represent the major antigen-presenting cell at the
maternal-fetal interface. Except for protecting the embryo with half of the paternal antigens …