Engineering organs and tissues with the spatial composition and organisation of their native
equivalents remains a major challenge. One approach to engineer such spatial complexity …

Recapitulation of the articular cartilage microenvironment for regenerative medicine
applications faces significant challenges due to the complex and dynamic biochemical and …

There has been unprecedented interest in recent years in the use of stem cells as therapy
for an array of diseases in companion animals. Stem cells have already been deployed …

A plethora of 3D and microfluidics-based culture models have been demonstrated in the
recent years with the ultimate aim to facilitate predictive in vitro models for pharmaceutical …

Articular cartilage injury is a prevalent clinical condition resulting from trauma, tumors,
infection, osteoarthritis, and other factors. The intrinsic lack of blood vessels, nerves, and …

Biofabrication has emerged as an attractive strategy to personalise medical care and
provide new treatments for common organ damage or diseases. While it has made impactful …

GAGs through the thickness of the scaffold. Utilizing specific binding peptides to guide
biomolecule concentration and placement mimics the dynamic, biologically relevant …

A layered gelatin-chitosan hydrogel with graded composition was prepared via
photocrosslinking to simulate the polysaccharide/collagen composition of the natural tissue …

Articular cartilage is a mechanically and structurally complex, lubricious tissue that permits
load-bearing and frictionless movement of our joints upon articulation. Unfortunately …

Osteoarthritis is a painful degenerative joint disease that could be better managed if tissue
engineers can develop methods to create long-term engineered articular cartilage tissue …