Double-strand breaks (DSBs) are deleterious DNA lesions and if left unrepaired result in
severe genomic instability. Cells use two main pathways to repair DSBs: homologous …

In response to even a single chromosomal double-strand DNA break, cells enact the DNA
damage checkpoint. This checkpoint triggers cell cycle arrest, providing time for the cell to …

DNA double-strand breaks (DSBs) are among the most deleterious forms of DNA lesions in
cells. Here we induced site-specific DSBs in yeast cells and monitored chromatin dynamics …

We have examined the role of checkpoint pathways in responding to a yku70 Δ defect in
budding yeast. We show that CHK1, MEC1, and RAD9 checkpoint genes are required for …

In response to DNA damage, cells engage a complex set of events that together comprise
the DNA-damage response (DDR). These events bring about the repair of the damage and …

Homology-dependent repair of DNA double-strand breaks (DSBs) initiates by the 5′–3′
resection of the DNA ends to create single-stranded DNA (ssDNA), the substrate for …

The precise DNA arrangement at chromosomal ends and the proteins involved in its
maintenance are of crucial importance for genome stability. For the yeast Saccharomyces …

The ends of eukaryotic chromosomes have long been defined as structures that must avoid
being detected as DNA breaks. They are protected from checkpoints, homologous …

ATP-binding cassette (ABC)-type ATPases are chemo-mechanical engines for diverse
biological pathways. ABC ATPase domains act not only in ABC transporters but also in DNA …

Proper maintenance of telomere length and structure is necessary for normal proliferation of
mammalian cells. Mammalian telomere length is regulated by a number of proteins …