Telomere dysfunction causes genomic instability. However, the mechanism that initiates this
instability when telomeres become short is unclear. We measured the mutation rate and loss …

Plant genetic engineering and transgenic technology are powerful ways to study the function
of genes and improve crop yield and quality in the past few years. However, only a few …

In Saccharomyces cerevisiae, telomere replication occurs in late S phase and is
accompanied by dynamic remodeling of its protein components. Here, we show that MRX …

Telomeres are the protective ends of linear chromosomes. Telomeric components have
been identified and described by their abilities to bind telomeric DNA, affect telomere repeat …

Abstract The Rad50: Mre11: Xrs2 (RMX) complex functions in repair of DNA double-strand
breaks (DSBs) by recombination and nonhomologous end-joining (NHEJ) and is also …

Telomeres are distinctive structures, composed of a repetitive DNA sequence and
associated proteins, which enable cells to distinguish chromosome ends from DNA double …

The ends of both double-strand breaks (DSBs) and telomeres undergo tightly regulated 5′
to 3′ resection. Resection of DNA ends, which is specifically inhibited during the G1 cell …

Aging is a complex biological process that occurs in all living organisms. Aging is initiated by
the gradual accumulation of biomolecular damage in cells leading to the loss of cellular …

In Saccharomyces cerevisiae, telomeric DNA is protected by a nonnucleosomal protein
complex, tethered by the protein Rap1. Rif and Sir proteins, which interact with Rap1p, are …

Trinucleotide repeats can form secondary structures, whose inappropriate repair or
replication can lead to repeat expansions. There are multiple loci within the human genome …