End resection initiates genomic instability in the absence of telomerase

JA Hackett, CW Greider - Molecular and cellular biology, 2003 - Taylor & Francis
Telomere dysfunction causes genomic instability. However, the mechanism that initiates this
instability when telomeres become short is unclear. We measured the mutation rate and loss …

[HTML][HTML] Artificial chromosome technology and its potential application in plants

M Kan, T Huang, P Zhao - Frontiers in Plant Science, 2022 - frontiersin.org
Plant genetic engineering and transgenic technology are powerful ways to study the function
of genes and improve crop yield and quality in the past few years. However, only a few …

[PDF][PDF] Late S phase-specific recruitment of Mre11 complex triggers hierarchical assembly of telomere replication proteins in Saccharomyces cerevisiae

H Takata, Y Tanaka, A Matsuura - Molecular cell, 2005 - cell.com
In Saccharomyces cerevisiae, telomere replication occurs in late S phase and is
accompanied by dynamic remodeling of its protein components. Here, we show that MRX …

A Quantitative Assay for Telomere Protection in Saccharomyces cerevisiae

ML DuBois, ZW Haimberger, MW McIntosh… - Genetics, 2002 - academic.oup.com
Telomeres are the protective ends of linear chromosomes. Telomeric components have
been identified and described by their abilities to bind telomeric DNA, affect telomere repeat …

Role of the Nuclease Activity of Saccharomyces cerevisiae Mre11 in Repair of DNA Double-Strand Breaks in Mitotic Cells

LK Lewis, F Storici, S Van Komen, S Calero, P Sung… - Genetics, 2004 - academic.oup.com
Abstract The Rad50: Mre11: Xrs2 (RMX) complex functions in repair of DNA double-strand
breaks (DSBs) by recombination and nonhomologous end-joining (NHEJ) and is also …

Telomeres and chromosomal instability

N Mathieu, L Pirzio, MA Freulet-Marrière… - Cellular and Molecular …, 2004 - Springer
Telomeres are distinctive structures, composed of a repetitive DNA sequence and
associated proteins, which enable cells to distinguish chromosome ends from DNA double …

[HTML][HTML] The MRX complex plays multiple functions in resection of Yku-and Rif2-protected DNA ends

D Bonetti, M Clerici, N Manfrini, G Lucchini… - PloS one, 2010 - journals.plos.org
The ends of both double-strand breaks (DSBs) and telomeres undergo tightly regulated 5′
to 3′ resection. Resection of DNA ends, which is specifically inhibited during the G1 cell …

[HTML][HTML] Genomic instability and cellular senescence: Lessons from the budding yeast

JW Lee, EBB Ong - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Aging is a complex biological process that occurs in all living organisms. Aging is initiated by
the gradual accumulation of biomolecular damage in cells leading to the loss of cellular …

Telomeric Protein Distributions and Remodeling Through the Cell Cycle in Saccharomyces cerevisiae

CD Smith, DL Smith, JL DeRisi… - Molecular biology of the …, 2003 - Am Soc Cell Biol
In Saccharomyces cerevisiae, telomeric DNA is protected by a nonnucleosomal protein
complex, tethered by the protein Rap1. Rif and Sir proteins, which interact with Rap1p, are …

Double-strand break repair pathways protect against CAG/CTG repeat expansions, contractions and repeat-mediated chromosomal fragility in Saccharomyces …

R Sundararajan, L Gellon, RM Zunder… - Genetics, 2010 - academic.oup.com
Trinucleotide repeats can form secondary structures, whose inappropriate repair or
replication can lead to repeat expansions. There are multiple loci within the human genome …