Conversion of a double-strand break into a telomere is a dangerous, potentially lethal event.
However, little is known about the mechanism and control of de novo telomere formation …

Telomeres must protect chromosome ends from being recognized and processed as double-
strand breaks. Identification of the factors involved in end protection, and the mechanisms by …

Generation of G-strand overhangs at Saccharomyces cerevisiae yeast telomeres depends
primarily on the MRX (Mre11-Rad50-Xrs2) complex, which is also necessary to maintain …

Telomeres protect chromosome ends and are distinguished from DNA double-strand breaks
(DSBs) by means of a specialized chromatin composed of DNA repeats bound by a …

MRE11 is a conserved multi-functional protein that is important for maintaining genomic
integrity in yeast and mammalian cells. By database searching, we identified a full-length …

The dramatic telomerase-dependent overelongation of telomeres in cells lacking Taz1
(ortholog of human TRF1/TRF2) or Rap1 implicates these proteins in restraint of telomerase …

Telomere structure allows cells to distinguish the natural chromosome ends from double-
strand breaks (DSBs). However, DNA damage response proteins are intimately involved in …

Telomeres constitute the ends of linear eukaryotic chromosomes. Due to the conventional
mode of DNA replication, telomeric DNA erodes at each cell division. To counteract this, a …

Saccharomyces cerevisiae strains lacking the Rad27p nuclease, a homolog of the
mammalian FEN-1 protein, display an accumulation of extensive single-stranded G-tails at …

Inactivation of the budding yeast telomere binding protein Cdc13 results in abnormal
telomeres (exposed long G-strands) and activation of the DNA damage checkpoint. In the …