Unlike ribonucleoprotein complexes that have a highly ordered overall architecture, such as
the ribosome, yeast telomerase appears to be much more loosely constrained. Here, we …

Telomere repeats in budding yeast are maintained at a constant average length and
protected ('capped'), in part, by mechanisms involving the TG1− 3 repeat‐binding protein …

The resection of DNA double-strand breaks (DSBs) into 3′ single-strand tails is the
initiating step of homology-dependent repair pathways. A key player in this process is the …

Using Drosophila as a model system, we identified here a stringent requirement for Mre11-
Rad50-Nbs (MRN) function in telomere protection during early embryonic development …

Cells must distinguish between broken chromosome ends and natural ends, or telomeres.
Broken chromosomes require repair, but telomeres need to be protected from repair …

The single-strand overhang present at telomeres plays a critical role in mediating both the
capping and telomerase regulation functions of telomeres. The telomere end-binding …

[Frontiers in Bioscience 17, 1715-1728, January 1, 2012] 1715 The role of shelterin in
maintaining telomere integrity Maria Pia Page 1 [Frontiers in Bioscience 17, 1715-1728 …

Telomeres have unique properties that distinguish natural chromosomal ends from
accidental DNA double-strand interruptions arising elsewhere in the genome. However, the …

MRX, an evolutionally conserved DNA damage response complex composed of Mre11,
Rad50 and Xrs2, is involved in DNA double strand break (DSB) repair, checkpoint activation …

Loss of heterozygosity (LOH), a causal event in tumorigenesis, frequently encompasses
multiple genetic loci and whole chromosome arms. However, the mechanisms leading to …