Immunogenicity of CAR T cells in cancer therapy
DL Wagner, E Fritsche, MA Pulsipher… - Nature reviews Clinical …, 2021 - nature.com
Patient-derived T cells genetically reprogrammed to express CD19-specific chimeric antigen
receptors (CARs) have shown remarkable clinical responses and are commercially …
receptors (CARs) have shown remarkable clinical responses and are commercially …
ImmunoPET: concept, design, and applications
W Wei, ZT Rosenkrans, J Liu, G Huang, QY Luo… - Chemical …, 2020 - ACS Publications
Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels
CCS Chini, TR Peclat, GM Warner, S Kashyap… - Nature …, 2020 - nature.com
Decreased NAD+ levels have been shown to contribute to metabolic dysfunction during
aging. NAD+ decline can be partially prevented by knockout of the enzyme CD38. However …
aging. NAD+ decline can be partially prevented by knockout of the enzyme CD38. However …
[HTML][HTML] Superparamagnetic iron oxide nanoparticles—Current and prospective medical applications
J Dulińska-Litewka, A Łazarczyk, P Hałubiec… - Materials, 2019 - mdpi.com
The recent, fast development of nanotechnology is reflected in the medical sciences.
Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are an excellent example. Thanks to …
Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are an excellent example. Thanks to …
Radioactive main group and rare earth metals for imaging and therapy
TI Kostelnik, C Orvig - Chemical reviews, 2018 - ACS Publications
Radiometals possess an exceptional breadth of decay properties and have been applied to
medicine with great success for several decades. The majority of current clinical use …
medicine with great success for several decades. The majority of current clinical use …
[HTML][HTML] Enzyme-linked immunosorbent assay for the quantitative/qualitative analysis of plant secondary metabolites
S Sakamoto, W Putalun, S Vimolmangkang… - Journal of natural …, 2018 - Springer
Immunoassays are antibody-based analytical methods for quantitative/qualitative analysis.
Since the principle of immunoassays is based on specific antigen–antibody reaction, the …
Since the principle of immunoassays is based on specific antigen–antibody reaction, the …
Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies
Amplification of epidermal growth factor receptor (EGFR) and its active mutant EGFRvIII
occurs frequently in glioblastoma (GBM). While EGFR and EGFRvIII play critical roles in …
occurs frequently in glioblastoma (GBM). While EGFR and EGFRvIII play critical roles in …
Ligand-targeted drug delivery
M Srinivasarao, PS Low - Chemical reviews, 2017 - ACS Publications
Safety and efficacy constitute the major criteria governing regulatory approval of any new
drug. The best method to maximize safety and efficacy is to deliver a proven therapeutic …
drug. The best method to maximize safety and efficacy is to deliver a proven therapeutic …
How nanophotonic label-free biosensors can contribute to rapid and massive diagnostics of respiratory virus infections: COVID-19 case
The global sanitary crisis caused by the emergence of the respiratory virus SARS-CoV-2
and the COVID-19 outbreak has revealed the urgent need for rapid, accurate, and affordable …
and the COVID-19 outbreak has revealed the urgent need for rapid, accurate, and affordable …
[HTML][HTML] Clarifying tissue clearing
DS Richardson, JW Lichtman - Cell, 2015 - cell.com
Biological specimens are intrinsically three dimensional; however, because of the obscuring
effects of light scatter, imaging deep into a tissue volume is problematic. Although efforts to …
effects of light scatter, imaging deep into a tissue volume is problematic. Although efforts to …