Membrane fusion is a universal feature of eukaryotic protein trafficking and is mediated by
the soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) family …

Although neuronal subtypes display unique synaptic organization and function, the
underlying transcriptional differences that establish these features are poorly understood. To …

Neurotransmitter release is stabilized by homeostatic plasticity. Presynaptic homeostatic
potentiation (PHP) operates on timescales ranging from minute-to life-long adaptations and …

Microtubules are essential to neuron shape and function. Acetylation of tubulin has the
potential to directly tune the behavior and function of microtubules in cells. Although …

Neurons exhibit a striking degree of functional diversity, each one tuned to the needs of the
circuitry in which it is embedded. A fundamental functional dichotomy occurs in activity …

Synaptic vesicle (SV) release probability (P r) is a key presynaptic determinant of synaptic
strength established by cell-intrinsic properties and further refined by plasticity. To …

In developing and mature nervous systems, diverse neuronal subtypes innervate common
targets to establish, maintain, and modify neural circuit function. A major challenge towards …

Ionotropic glutamate receptors (GluRs) are targets for modulation in Hebbian and
homeostatic synaptic plasticity and are remodeled by development, experience, and …

Synaptic heterogeneity is a hallmark of complex nervous systems that enables reliable and
responsive communication in neural circuits. In this study, we investigated the contributions …

Heparan sulfate proteoglycans (HSPGs) form essential components of the extracellular
matrix (ECM) and basement membrane (BM) and have both structural and signaling roles …