Advances in acute ischemic stroke therapy
Y Xiong, AK Wakhloo, M Fisher - Circulation research, 2022 - Am Heart Assoc
The treatment of acute ischemic stroke continues to advance. The mainstay of treatment
remains intravenous thrombolysis with alteplase. Recent studies demonstrated that later …
remains intravenous thrombolysis with alteplase. Recent studies demonstrated that later …
Direct mechanical thrombectomy versus combined intravenous and mechanical thrombectomy in large-artery anterior circulation stroke: a topical review
Fischer et al Mechanical Thrombectomy vs Bridging Thrombolysis 2913 and before EVT in
bridging patients. 19 Relevant recanalization rates before EVT in bridging patients were …
bridging patients. 19 Relevant recanalization rates before EVT in bridging patients were …
Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial
U Fischer, J Kaesmacher, D Strbian, O Eker… - The Lancet, 2022 - thelancet.com
Background Whether thrombectomy alone is equally as effective as intravenous alteplase
plus thrombectomy remains controversial. We aimed to determine whether thrombectomy …
plus thrombectomy remains controversial. We aimed to determine whether thrombectomy …
Neutrophil-to-lymphocyte ratio and symptomatic hemorrhagic transformation in ischemic stroke patients undergoing revascularization
M Świtońska, N Piekuś-Słomka, A Słomka, P Sokal… - Brain Sciences, 2020 - mdpi.com
Objectives: Symptomatic hemorrhagic transformation (sHT) is a life-threatening complication
of acute ischemic stroke (AIS). The early identification of the patients at increased risk of sHT …
of acute ischemic stroke (AIS). The early identification of the patients at increased risk of sHT …
Combined intravenous thrombolysis and thrombectomy vs thrombectomy alone for acute ischemic stroke: a pooled analysis of the SWIFT and STAR studies
JM Coutinho, DS Liebeskind, LA Slater… - JAMA …, 2017 - jamanetwork.com
Importance Mechanical thrombectomy (MT) improves clinical outcomes in patients with
acute ischemic stroke (AIS) caused by a large vessel occlusion. However, it is not known …
acute ischemic stroke (AIS) caused by a large vessel occlusion. However, it is not known …
Time to treatment with intravenous thrombolysis before thrombectomy and functional outcomes in acute ischemic stroke: a meta-analysis
J Kaesmacher, F Cavalcante, M Kappelhof… - JAMA, 2024 - jamanetwork.com
Importance The benefit of intravenous thrombolysis (IVT) for acute ischemic stroke declines
with longer time from symptom onset, but it is not known whether a similar time dependency …
with longer time from symptom onset, but it is not known whether a similar time dependency …
Direct mechanical thrombectomy in tPA-ineligible and-eligible patients versus the bridging approach: a meta-analysis
Background Whether pretreatment with intravenous thrombolysis prior to mechanical
thrombectomy (IVT+ MTE) adds additional benefit over direct mechanical thrombectomy …
thrombectomy (IVT+ MTE) adds additional benefit over direct mechanical thrombectomy …
Hemorrhagic transformations after thrombectomy: risk factors and clinical relevance
J Kaesmacher, M Kaesmacher, C Maegerlein… - Cerebrovascular …, 2017 - karger.com
Background: Hemorrhagic transformation (HT) is a major complication of acute ischemic
stroke, potentially associated with clinical deterioration. We attempted to identify risk factors …
stroke, potentially associated with clinical deterioration. We attempted to identify risk factors …
Rapid alteplase administration improves functional outcomes in patients with stroke due to large vessel occlusions: meta-analysis of the noninterventional arm from …
Background and Purpose—We report the relation of onset-to-treatment time and door-to-
needle time with functional outcomes and mortality among patients with ischemic stroke with …
needle time with functional outcomes and mortality among patients with ischemic stroke with …
Swift direct: Solitaire™ with the intention for thrombectomy plus intravenous t-PA versus direct Solitaire™ Stent-retriever thrombectomy in acute anterior circulation …
U Fischer, J Kaesmacher, PS Plattner… - … Journal of Stroke, 2022 - journals.sagepub.com
Rationale Whether treatment with intravenous alteplase prior to mechanical thrombectomy
(MT) in acute ischemic stroke patients with large vessel occlusion is beneficial remains …
(MT) in acute ischemic stroke patients with large vessel occlusion is beneficial remains …