[HTML][HTML] Cellular senescence in brain aging

E Sikora, A Bielak-Zmijewska, M Dudkowska… - Frontiers in aging …, 2021 - frontiersin.org
Aging of the brain can manifest itself as a memory and cognitive decline, which has been
shown to frequently coincide with changes in the structural plasticity of dendritic spines …

Targeting autophagy in ischemic stroke: from molecular mechanisms to clinical therapeutics

A Ajoolabady, S Wang, G Kroemer… - Pharmacology & …, 2021 - Elsevier
Stroke constitutes the second leading cause of death and a major cause of disability
worldwide. Stroke is normally classified as either ischemic or hemorrhagic stroke (HS) …

Metformin for cardiovascular protection, inflammatory bowel disease, osteoporosis, periodontitis, polycystic ovarian syndrome, neurodegeneration, cancer …

M Ala, M Ala - ACS pharmacology & translational science, 2021 - ACS Publications
Diabetes is accompanied by several complications. Higher prevalence of cancers,
cardiovascular diseases, chronic kidney disease (CKD), obesity, osteoporosis, and …

Macroautophagy and aging: The impact of cellular recycling on health and longevity

JL Nieto-Torres, M Hansen - Molecular aspects of medicine, 2021 - Elsevier
Aging is associated with many deleterious changes at the cellular level, including the
accumulation of potentially toxic components that can have devastating effects on health. A …

[HTML][HTML] The mitochondrial permeability transition: nexus of aging, disease and longevity

H Rottenberg, JB Hoek - Cells, 2021 - mdpi.com
The activity of the mitochondrial permeability transition pore, mPTP, a highly regulated multi-
component mega-channel, is enhanced in aging and in aging-driven degenerative …

[HTML][HTML] Physical exercise, a potential non-pharmacological intervention for attenuating neuroinflammation and cognitive decline in Alzheimer's disease patients

S Ribarič - International journal of molecular sciences, 2022 - mdpi.com
This narrative review summarises the evidence for considering physical exercise (PE) as a
non-pharmacological intervention for delaying cognitive decline in patients with Alzheimer's …

Modulating autophagy and mitophagy as a promising therapeutic approach in neurodegenerative disorders

J Mishra, GK Bhatti, A Sehrawat, C Singh, A Singh… - Life sciences, 2022 - Elsevier
The high prevalence of neurodegenerative diseases has become a major public health
challenge and is associated with a tremendous burden on individuals, society and federal …

Lifestyle strategies to promote proteostasis and reduce the risk of Alzheimer's disease and other proteinopathies

MF Almeida, KLG Farizatto, RS Almeida… - Ageing Research …, 2023 - Elsevier
Unhealthy lifestyle choices, poor diet, and aging can have negative influences on cognition,
gradually increasing the risk for mild cognitive impairment (MCI) and the continuum …

[HTML][HTML] New molecular targets for antidepressant drugs

J Kornhuber, E Gulbins - Pharmaceuticals, 2021 - mdpi.com
Major depressive disorder (MDD) is a common and severe mental disorder that is usually
recurrent and has a high risk of suicide. This disorder manifests not only with psychological …

Aerobic Exercise Regulates Apoptosis through the PI3K/Akt/GSK‐3β Signaling Pathway to Improve Cognitive Impairment in Alzheimer's Disease Mice

Y Peng, R Chi, G Liu, W Tian, J Zhang… - Neural …, 2022 - Wiley Online Library
Neuronal apoptosis is an important factor in the etiology of Alzheimer's disease (AD).
Aerobic exercise (AE) enhances learning and memory, improves cognitive impairment …