[HTML][HTML] Cellular senescence in brain aging
E Sikora, A Bielak-Zmijewska, M Dudkowska… - Frontiers in aging …, 2021 - frontiersin.org
Aging of the brain can manifest itself as a memory and cognitive decline, which has been
shown to frequently coincide with changes in the structural plasticity of dendritic spines …
shown to frequently coincide with changes in the structural plasticity of dendritic spines …
Targeting autophagy in ischemic stroke: from molecular mechanisms to clinical therapeutics
A Ajoolabady, S Wang, G Kroemer… - Pharmacology & …, 2021 - Elsevier
Stroke constitutes the second leading cause of death and a major cause of disability
worldwide. Stroke is normally classified as either ischemic or hemorrhagic stroke (HS) …
worldwide. Stroke is normally classified as either ischemic or hemorrhagic stroke (HS) …
Metformin for cardiovascular protection, inflammatory bowel disease, osteoporosis, periodontitis, polycystic ovarian syndrome, neurodegeneration, cancer …
M Ala, M Ala - ACS pharmacology & translational science, 2021 - ACS Publications
Diabetes is accompanied by several complications. Higher prevalence of cancers,
cardiovascular diseases, chronic kidney disease (CKD), obesity, osteoporosis, and …
cardiovascular diseases, chronic kidney disease (CKD), obesity, osteoporosis, and …
Macroautophagy and aging: The impact of cellular recycling on health and longevity
JL Nieto-Torres, M Hansen - Molecular aspects of medicine, 2021 - Elsevier
Aging is associated with many deleterious changes at the cellular level, including the
accumulation of potentially toxic components that can have devastating effects on health. A …
accumulation of potentially toxic components that can have devastating effects on health. A …
[HTML][HTML] The mitochondrial permeability transition: nexus of aging, disease and longevity
H Rottenberg, JB Hoek - Cells, 2021 - mdpi.com
The activity of the mitochondrial permeability transition pore, mPTP, a highly regulated multi-
component mega-channel, is enhanced in aging and in aging-driven degenerative …
component mega-channel, is enhanced in aging and in aging-driven degenerative …
[HTML][HTML] Physical exercise, a potential non-pharmacological intervention for attenuating neuroinflammation and cognitive decline in Alzheimer's disease patients
S Ribarič - International journal of molecular sciences, 2022 - mdpi.com
This narrative review summarises the evidence for considering physical exercise (PE) as a
non-pharmacological intervention for delaying cognitive decline in patients with Alzheimer's …
non-pharmacological intervention for delaying cognitive decline in patients with Alzheimer's …
Modulating autophagy and mitophagy as a promising therapeutic approach in neurodegenerative disorders
The high prevalence of neurodegenerative diseases has become a major public health
challenge and is associated with a tremendous burden on individuals, society and federal …
challenge and is associated with a tremendous burden on individuals, society and federal …
Lifestyle strategies to promote proteostasis and reduce the risk of Alzheimer's disease and other proteinopathies
Unhealthy lifestyle choices, poor diet, and aging can have negative influences on cognition,
gradually increasing the risk for mild cognitive impairment (MCI) and the continuum …
gradually increasing the risk for mild cognitive impairment (MCI) and the continuum …
[HTML][HTML] New molecular targets for antidepressant drugs
J Kornhuber, E Gulbins - Pharmaceuticals, 2021 - mdpi.com
Major depressive disorder (MDD) is a common and severe mental disorder that is usually
recurrent and has a high risk of suicide. This disorder manifests not only with psychological …
recurrent and has a high risk of suicide. This disorder manifests not only with psychological …
Aerobic Exercise Regulates Apoptosis through the PI3K/Akt/GSK‐3β Signaling Pathway to Improve Cognitive Impairment in Alzheimer's Disease Mice
Y Peng, R Chi, G Liu, W Tian, J Zhang… - Neural …, 2022 - Wiley Online Library
Neuronal apoptosis is an important factor in the etiology of Alzheimer's disease (AD).
Aerobic exercise (AE) enhances learning and memory, improves cognitive impairment …
Aerobic exercise (AE) enhances learning and memory, improves cognitive impairment …