[HTML][HTML] HMGB family proteins: Potential biomarkers and mechanistic factors in cardiovascular diseases
X Zheng, J Lu, J Liu, L Zhou, Y He - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Cardiovascular disease (CVD) is the most fatal disease that causes sudden death, and
inflammation contributes substantially to its occurrence and progression. The prevalence of …
inflammation contributes substantially to its occurrence and progression. The prevalence of …
The prevalence of pulmonary hypertension in post-tuberculosis and active tuberculosis populations: a systematic review and meta-analysis
JK van Heerden, EH Louw… - European …, 2024 - Eur Respiratory Soc
Background: The prevalence of tuberculosis (TB)-associated pulmonary hypertension (PH)
has not previously been quantified, resulting in an underappreciated burden of disease. We …
has not previously been quantified, resulting in an underappreciated burden of disease. We …
SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells
K Yang, S Liu, H Yan, W Lu, X Shan, H Chen… - … and Targeted Therapy, 2023 - nature.com
Exposure to the spike protein or receptor-binding domain (S-RBD) of SARS-CoV-2
significantly influences endothelial cells and induces pulmonary vascular endotheliopathy …
significantly influences endothelial cells and induces pulmonary vascular endotheliopathy …
Polo-like kinase 1 promotes pulmonary hypertension
R Chen, H Wang, C Zheng, X Zhang, L Li, S Wang… - Respiratory …, 2023 - Springer
Background Pulmonary hypertension (PH) is a lethal vascular disease with limited
therapeutic options. The mechanistic connections between alveolar hypoxia and PH are not …
therapeutic options. The mechanistic connections between alveolar hypoxia and PH are not …
[HTML][HTML] Expression and regulation of HIF-1a in hypoxic pulmonary hypertension: Focus on pathological mechanism and Pharmacological Treatment
JJ Wan, J Yi, FY Wang, C Zhang… - International Journal of …, 2024 - ncbi.nlm.nih.gov
Abstract Hypoxia inducible factor-1 (HIF-1), a heterodimeric transcription factor, is composed
of two subunits (HIF-1α and HIF-1β). It is considered as an important transcription factor for …
of two subunits (HIF-1α and HIF-1β). It is considered as an important transcription factor for …
[HTML][HTML] The Early Detection of Pulmonary Hypertension
L Ley, F Grimminger, M Richter, K Tello… - Deutsches Ärzteblatt …, 2023 - ncbi.nlm.nih.gov
Background Up to 1% of the world population and 10% of all persons over age 65 suffer
from pulmonary hypertension (PH). The latency from the first symptom to the diagnosis is …
from pulmonary hypertension (PH). The latency from the first symptom to the diagnosis is …
[HTML][HTML] Salidroside protects pulmonary artery endothelial cells against hypoxia-induced apoptosis via the AhR/NF-κB and Nrf2/HO-1 pathways
W Lei, M Chen, Z Huang, X Chen, J Wang, J Zheng… - Phytomedicine, 2024 - Elsevier
Background The apoptosis of pulmonary artery endothelial cells (PAECs) is an important
factor contributing to the development of pulmonary hypertension (PH), a serious cardio …
factor contributing to the development of pulmonary hypertension (PH), a serious cardio …
Neutrophil extracellular traps promote proliferation of pulmonary smooth muscle cells mediated by CCDC25 in pulmonary arterial hypertension
H Sun, Z Du, X Zhang, S Gao, Z Ji, G Luo, S Pan - Respiratory Research, 2024 - Springer
Background Previous studies have indicated that neutrophil extracellular traps (NETs) play a
pivotal role in pathogenesis of pulmonary arterial hypertension (PAH). However, the specific …
pivotal role in pathogenesis of pulmonary arterial hypertension (PAH). However, the specific …
Causal effect of interleukin (IL)-6 on blood pressure and hypertension: A mendelian randomization study
O Wu, Y Wu, X Zhang, W Liu, H Zhang, S Khederzadeh… - Immunogenetics, 2024 - Springer
To examine whether circulating interleukin-6 (IL-6) levels (CirIL6) have a causal effect on
blood pressure using Mendelian randomization (MR) methods. We used data from genome …
blood pressure using Mendelian randomization (MR) methods. We used data from genome …
Hypoxic perfusion of pulmonary arterial vasa vasorum increases pulmonary arterial pressure
EL Heise, J Salman, KS Webs… - … of Physiology-Lung …, 2024 - journals.physiology.org
The pathophysiology of pulmonary hypertension (PH) is not fully understood. Here, we
tested the hypothesis that hypoxic perfusion of the vasa vasorum of the pulmonary arterial …
tested the hypothesis that hypoxic perfusion of the vasa vasorum of the pulmonary arterial …