The antiphospholipid syndrome: from pathophysiology to treatment

S Negrini, F Pappalardo, G Murdaca, F Indiveri… - Clinical and …, 2017 - Springer
Antiphospholipid antibody syndrome (APS) is an autoimmune acquired thrombophilia
characterized by recurrent thrombosis and pregnancy morbidity in the presence of …

Mechanisms of endothelial dysfunction in antiphospholipid syndrome: association with clinical manifestations

M Velásquez, M Rojas, VM Abrahams… - Frontiers in …, 2018 - frontiersin.org
The endothelium is a monolayer of cells that covers the inner surface of blood vessels and
its integrity is essential for the maintenance of vascular health. Endothelial dysfunction is a …

The vasculopathy of juvenile dermatomyositis

C Papadopoulou, LJ McCann - Frontiers in pediatrics, 2018 - frontiersin.org
Juvenile dermatomyositis (JDM) is a rare autoimmune disease mainly characterized by
muscle and skin involvement. Vasculopathy is considered central to the pathogenesis of the …

HIV antivirals affect endothelial activation and endothelial-platelet crosstalk

AA Khawaja, KA Taylor, AO Lovell, M Nelson… - Circulation …, 2020 - Am Heart Assoc
Rationale: People living with HIV on effective antiretroviral therapy are at increased risk of
cardiovascular complications, possibly due to off-target drug effects. Some studies have …

[HTML][HTML] Blood microvesicles: from proteomics to physiology

JD Tissot, G Canellini, O Rubin… - Translational …, 2013 - Elsevier
Phospholipid vesicles of less than 1 μm are present in blood in physiological state and their
concentration may vary under pathological conditions. Various names such as exosomes …

[HTML][HTML] Interactions between rivaroxaban and antiphospholipid antibodies in thrombotic antiphospholipid syndrome

DRJ Arachchillage, IJ Mackie, M Efthymiou… - Journal of thrombosis …, 2015 - Elsevier
Introduction Rivaroxaban can affect lupus anticoagulant (LA) testing and antiphospholipid
antibodies (aPL) may interfere with the anticoagulant action of rivaroxaban. Aims To …

The vasculopathy of juvenile dermatomyositis: endothelial injury, hypercoagulability, and increased arterial stiffness

C Papadopoulou, Y Hong, P Krol… - Arthritis & …, 2021 - Wiley Online Library
Objective Vasculopathy is considered central to the pathogenesis of juvenile
dermatomyositis (DM) and is associated with severe extramuscular manifestations. We …

Differences in endothelial activation and dysfunction induced by antiphospholipid antibodies among groups of patients with thrombotic, refractory, and non-refractory …

M Velásquez, LF Peláez, M Rojas… - Frontiers in …, 2021 - frontiersin.org
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by pregnancy
morbidity or thrombosis and persistent antiphospholipid antibodies (aPL) that bind to the …

Extracellular vesicles and antiphospholipid syndrome: state-of-the-art and future challenges

U Štok, S Čučnik, S Sodin-Šemrl, P Žigon - International Journal of …, 2021 - mdpi.com
Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by
thromboembolism, obstetric complications, and the presence of antiphospholipid antibodies …

Anti-β2GPI antibodies stimulate endothelial cell microparticle release via a nonmuscle myosin II motor protein-dependent pathway

V Betapudi, G Lominadze, L Hsi… - Blood, The Journal …, 2013 - ashpublications.org
The antiphospholipid syndrome is characterized by thrombosis and recurrent fetal loss in
patients with antiphospholipid antibodies (APLAs). Most pathogenic APLAs are directed …